antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2022-67-7-8-51-56antibiotics-948Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ И ПРАКТИКАGUIDELINES FOR PRACTITIONERSИнфекция Helicobacter pylori (хеликобактерной инфекции) у детей, больных астмой, и её связь с тяжестью заболеванияEvaluation of Helicobacter pylori Infection in Asthmatic Children and Its Relationship With Severity of the Diseasehttps://orcid.org/0000-0002-5085-5459БАЗМАМУНХ.BAZMAMOUNH.

Хасан Базмамун — доктор, доцент, отделение детской гастроэнтерологии

Хамадан

Hassan Bazmamoun — MD. Associate professor. Department of pediatric gastroenterology

Hamadan

https://orcid.org/0000-0003-1799-7866БАХРАМИВ.BAHRAMIV.

Вахид Бахрами — врач общей практики

Хамадан

Vahid Bahrami — MD. General physician

Hamadan

https://orcid.org/0000-0002-3357-0662КАЛВАНДИГ.KALVANDIG.

Голамреза Калванди — доктор, доцент, отделение детской гастроэнтерологии

Хамадан

Gholamreza Kalvandi — MD. Associate professor. Department of pediatric gastroenterology

Hamadan

https://orcid.org/0000-0003-4994-0936МОРАДИА.MORADIA.

Аббас Моради — магистр наук, кафедра общественной медицины

Хамадан

Abbas Moradi — MSc. Department of community medicine

Hamadan

https://orcid.org/0000-0003-2842-4836ЭСЛАМЯНМ. Х.ESLAMIANM. H.

Мохаммед Хоссейн Эсламян — доктор, доцент, кафедра аллергологии и клинической иммунологии

Хамадан, площадь Ресалат, бульвар Аятоллы Мотахари, Больница Бесат

Mohammad Hossein Eslamian — MD. (Corresponding author) Assistant professor. Department of allergy and clinical immunology

Hamadan

zblresearchcenter@gmail.comШАХРАМЯНИ.SHAHRAMIANI.

Ирадж Шахрамян — Научно-исследовательский центр детской гастроэнтерологии и гепатологии

Заболь

Iraj Shahramian — Pediatric Gastroenterology and Hepatology research Center

Zabol

ПАРУЙЕФ.PAROOIEF.

Фатема Паруйе — Научно-исследовательский центр детской гастроэнтерологии и гепатологии

Заболь

Fateme Parooie — Pediatric Gastroenterology and Hepatology research Center

Zabol

Хамаданский университет медицинских наукИранHamadan University of Medical SciencesIslamic Republic of IranЗабольский университет медицинских наукИранZabol University of Medical SciencesIslamic Republic of Iran202217112022677-85156Copyright © БАЗМАМУН Х., БАХРАМИ В., КАЛВАНДИ Г., МОРАДИ А., ЭСЛАМЯН М.H., ШАХРАМЯН И., ПАРУЙЕ Ф., 20222022БАЗМАМУН Х., БАХРАМИ В., КАЛВАНДИ Г., МОРАДИ А., ЭСЛАМЯН М., ШАХРАМЯН И., ПАРУЙЕ Ф.BAZMAMOUN H., BAHRAMI V., KALVANDI G., MORADI A., ESLAMIAN M.H., SHAHRAMIAN I., PAROOIE F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/948

Актуальность. Астма является одним из самых распространённых заболеваний, которым страдают более 300 млн человек во всем мире. Helicobacter pylori является одной из наиболее распространённых инфекций, в результате её колонизации слизистой оболочки желудка высвобождаются белки острой фазы, что может выявить патогенную связь между хеликобактерной инфекцией и воспалительными заболеваниями. Цель исследования — оценить хеликобактерную инфекцию у детей с астмой и её связь с тяжестью течения астмы.Материал и методы. В этом контролируемом исследовании приняло участие 94 пациента (в возрасте от 2 до 18 лет), которые были разделены на две равные группы — с астмой и без астмы. Хеликобактерную инфекцию оценивали в двух группах с использованием сывороточных антител против H.pylori (IgG). Данные были проанализированы с использованием программного обеспечения SPSS 16. Были использованы статистические методы — критерий хи-квадрат и Т-критерий. Значение p<0,05 считалось статистически значимым.Результаты. В астматической группе 36,2% случаев, а в контрольной группе 48,9% случаев имели положительный результат теста на H.pylori (p=0,211). Выявлена достоверная связь между инфекцией H.pylori и продолжительностью астмы (p=0,002), и возрастом пациентов (p=0,04). Не было выявлено значимой связи между хеликобактерной инфекцией и полом, тяжестью астмы, семейным анамнезом астмы и тестами функции лёгких.Вывод. Результаты этого исследования показали, что количество инфицированных H.pylori детей с астмой было ниже, чем в контрольной группе, но эта разница не была статистически значимой. Также была выявлена достоверная связь между инфекцией H.pylori, длительностью астмы и возрастом больных.

Background. Asthma is one of the most common diseases in the world that affects more than 300 million people worldwide. Helicobacter pylori is one of the most common infection worldwide and its colonization in the gastric mucosa releases acute phase proteins that may reveal the pathogenic relationship between the infection and inflammatory diseases. The aim of this study was to evaluate of H.pylori infection in asthmatic children and its relationship with the severity of asthma.Methods. In this case-control study, 94 patients (aged 2 to 18 years) were divided in two equal groups of asthmatic and non-asthmatic patients. H.pylori infection was assessed in two groups using serum anti-Helicobacter pylori antibody (IgG). Data were analyzed using SPSS 16 software. Chi-square test and T-test were performed. P<0.05 was considered statistically significant.Results. 36.2% of cases in asthmatic group and 48.9% of cases in control group had positive H.pylori test (P=0. 211). There was a significant relationship between H.pylori infection and the duration of asthma (P=0.002), as well as the age of patients (P=0.04). There was no significant relationship between Helicobacter pylori infection with patients’ gender severity of asthma, family history of asthma and pulmonary function tests.Conclusion. Results of this study showed that the incidence of H.pylori infection was lower in asthmatic children than the control group but this difference was not statistically significant. Also, there was a significant relationship between H.pylori infection with duration of asthma and age of the patients.

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The authors declare that there are no conflicts of interest present.