Analysis of The Antibiotic Resistance Problem
https://doi.org/10.37489/0235-2990-2023-68-5-6-39-48
Abstract
Antibiotic resistance is a global health problem. Its solution requires concerted efforts on the scale of global cooperation. Programs to prevent the development of antibiotic resistance, as well as to stimulate the development of new drugs with antimicrobial activity are implemented in a lot of countries. The use of antibacterial drugs, including inappropriate use, has increased during the COVID-19 pandemic, which may contribute to the growth of antibiotic resistance. The aim of this study is to assess the measures aimed at combating the growing antibiotic resistance in the world, analyze the market of antimicrobial drugs in the Russian Federation, as well as collect and process information on the antibiotic resistance of microorganisms that cause infectious diseases that develop against the backdrop of COVID-19. The analysis of the state register of the Russian Federation for antibacterial drugs was carried out. Mathematical and statistical processing of antibiotic resistance was performed according to the data of the European Surveillance Atlas of Infectious Diseases for Klebsiella pneumonia in relation to fluoroquinolones, aminoglycosides, third-generation cephalosporins, as well as combined resistance to these antibacterial drugs over the past sixteen years.
About the Authors
M. A. Maistrenko
Ryazan State Medical University named after academician I. P. Pavlov
Russian Federation
Competing Interests:
Russian Federation
Assistant Professor at the Department of Management and Economics of Pharmacy
105 Mayakovskogo st., Ryazan State Medical University, Ryazan, 390000
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
E. N. Yakusheva
Ryazan State Medical University named after academician I. P. Pavlov
Russian Federation
Competing Interests:
Russian Federation
D. Sc. in Medicine, Professor, Head of Pharmacology Department with the Course of Pharmacy of the Continuing Professional Education Faculty
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
D. S. Titov
Ryazan State Medical University named after academician I. P. Pavlov
Russian Federation
Competing Interests:
Russian Federation
Ph. D. in Biology, Head of the Department of Management and Economics of Pharmacy
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
References
1. Strachunskii L.S., Kozlov S.N. Sovremennaya antimikrobnaya khimioterapiya. Rukovodstvo dlya vrachei. Moscow: Borges, 2002. (in Russian)
2. Beloborodova N.V., Zuev E.V., Zamyatin M.N., Gusarov V.G. Causal Therapy of COVID-19: Critical Review and Prospects. Obshchaya Reanimatologiya = General Reanimatology. 2020; 16 (6): 65–90. doi: https://doi.org/110.15360/1813-9779-2020-4-0-1. (in Russian and English)
3. Antimicrobial Resistance Global Report on Surveillance; 2014. World Health Organization.
4. World Health Organization [Internet] Geneva. Record number of countries contribute data revealing disturbing rates of antimicrobial resistance. [updated 2020 Jun 1; cited 2021 Oct 10] Available from: https://www.who.int/ru/news/item/01-06-2020-record-number-ofcountries-contribute-data-revealing-disturbing-rates-of-antimicrobialresistance.
5. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP) [Internet]. About Antibiotic Resistance [updated 2020 Mar 13; cited 2021 Sept 20] Available from: https://www.cdc.gov/drugresistance/about.html.
6. Ivanchik N.V., Chagaryan A.N., Sukhorukova M.V., Kozlov R.S., Dekhnich A.V., Krechikova O.I. et al. Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017». Klinicheskaja Mikrobiologija i Antimikrobnaja Khimioterapija. 2019; 21 (3): 230–237. doi: https://doi.org/10.36488/cmac. 2019.3.230-237. (in Russian)
7. Programma SKAT (Strategiya Kontrolya Antimikrobnoi Terapii) pri okazanii statsionarnoi meditsinskoi pomoshchi: Rossiiskie klinicheskie rekomendatsii. / Red. S.V. Yakovleva, N.I. Briko, S.V. Sidorenko, D.N. Protsenko. Moscow: Izdatel'stvo «Pero», 2018. (in Russian)
8. Открытая база данных AMRmap 2.4[Internet] Available from: https://amrmap.ru/.
9. Kuzmenkov A.Yu., Vinogradova A.G., Trushin I.V., Eidelshtein M.V., Avramenko A.A., Dekhnich A.V., Kozlov R.S. AMRmap — antibiotic resistance surveillance system in Russia. Klinicheskaja Mikrobiologija i Antimikrobnaja Himioterapija. 2021; 23 (2): 198–204. doi: https://doi.org/10.36488/cmac.2021.2.198204. (in Russian)
10. Vinogradova A.G., Kuzmenkov A.Yu. Application of AMRmap: «from the general to specific» approach by the example of Klebsiella pneumoniae. Klinicheskaja Mikrobiologija i Antimikrobnaja Khimioterapija. 2019; 21 (2): 181–186. doi: https://doi.org/ 10.36488/cmac.2019.2.181-186. (in Russian)].
11. minzdrav.gov.ru [интернет] Министерство Здравоохранения Российской Федерации [доступ от 20.10.2021] Доступ по ссылке https://minzdrav.gov.ru/news/2017/09/01/6039-minzdrav-rossii-razrabotal-i-vnes-v-pravitelstvo-rossiyskoy-federatsii-strategiyu-preduprezhdeniya-rasprostraneniya-antimikrobnoy-rezistentnosti-v-rossiyskoy-federatsii-na-period-do-2030-goda.
12. Robertson J., Vlahović-Palčevski V., Iwamoto K., Högberg L.D., Godman B., Monnet D.L., Garner S., Weist K. Variations in the Consumption of Antimicrobial Medicines in the European Region, 2014–2018: Findings and Implications from ESAC-Net and WHO Europe. Front Pharmacol. 2021; 12: 639207. doi: 10.3389/fphar.2021.639207.
13. World Health Organization [Internet] Geneva. Antibiotic resistance. [updated 2020 Jul 31; cited 2021 Dec 10] Available from: https://www.who.int/ru/news-room/fact-sheets/detail/antibiotic-resistance.
14. Edinyj strukturirovannyj spravochnik-katalog lekarstvennykh preparatov/ Unified structured directory-catalog of medicines, https://esklp.egisz.rosminzdrav.ru/ dostup 21.10.2022. (in Russian)].
15. Website of National Institute for Health and Care Excellence [NICE] https://www.nice.org.uk/guidance.
16. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infektsii (COVID-19). Vremennye metodicheskie rekomendatsii MZ RF. Versiya 7 ot 03.06.2020 [dostup ot 21.10.2021] Dostup po ssylke https://static-0.rosminzdrav.ru/system/attachments/attaches/000/050/584/original/03062020_MR_COVID-19_v7.pdf. (in Russian)
17. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infektsii (COVID-19). Vremennye metodicheskie rekomendatsii MZ RF. Versiya 10 ot 08.02.2021 [dostup ot 21.10.2021] Dostup po ssylke https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/054/588/original/%D0%92%D1%80%D0%B5%D0%BC%D0%B5%D0%BD%D0%BD%D1%8B%D0%B5_%D0%9C%D0%A0_COVID-19_%28v.10%29-08.02.2021_%281%29.pdf. (in Russian)
18. Food and Drug Administration [Internet] www.fda.gov. Generating antibiotic incentives now analysis [updated 2020; cited 2021 Oct 10] Available from: GENERATING ANTIBIOTIC INCENTIVES NOW (fda.gov).
19. Novosti OON. VOZ: nuzhny novye antibiotiki i kak mozhno skoree [dostup ot 20.10.2021] Dostup po ssylke https://news.un.org/ru/story/2020/01/1370792 (in Russian)
20. Otkrytaya baza dannykh: Surveillance Atlas of Infectious Diseases [cited 2021 Oct 30] Available from: https://atlas.ecdc.europa.eu/public/index.aspx (in Russian)
21. Gosudarstvennyj reestr lekarstvennykh sredstv 2021. http//grls.rosminzdrav.ru dostup 10.08.2021. (in Russian)
22. World Health Organization [Internet] Geneva. 2017 [updated 2017 Feb 27; cited 2021 Oct 30] Available from: https://www.who.int/ru/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed.
23. Zaitsev A.A. Opportunities in the Context of the COVID-19 Pandemic. Prakticheskaya Pul'monologiya. 2020; 1: 14–20 (in Russian).
24. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infektsii (COVID-19). Vremennye metodicheskie rekomendatsii MZ RF. Versiya 13 ot 14.10.2021 [dostup ot 20.10.2021] Dostup po ssylke https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/058/211/original/BMP-13.pdf 19_compressed.pdf. (in Russian)
Review
For citations:
Maistrenko M.A., Yakusheva E.N., Titov D.S. Analysis of The Antibiotic Resistance Problem. Antibiot Khimioter = Antibiotics and Chemotherapy. 2023;68(5-6):39-48. (In Russ.) https://doi.org/10.37489/0235-2990-2023-68-5-6-39-48
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