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Антибиотики и Химиотерапия

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Рифаксимин-альфа и другие кристаллические формы рифаксимина: есть ли отличия?

https://doi.org/10.37489/0235-2990-2020-65-7-8-52-62

Полный текст:

Аннотация

Рифаксимин - антибиотик, для которого характерен полиморфизм. У рифаксимина существуют различные кристаллические формы с разными фармакологическими характеристиками. Рифаксимин действует локально в пищеварительном тракте, поэтому важно, чтобы его абсорбция была минимальной, а концентрация в просвете кишечника высокой. Абсорбция в кишечнике других кристаллических форм рифаксимина более значима по сравнению с рифаксимином-α (Альфа Нормикс®). Различия в фармакокинетике кристаллических форм рифаксимина могут влиять на его эффективность и безопасность, особенно у пациентов с хроническими заболеваниями (состояние иммунодефицита и в условиях «leaky gut» на фоне цирроза печени), которым требуются длительные курсы терапии. Рифаксимин-α (Альфа Нормикс®) обладает уникальным действием, так как кроме местного антибактериального действия демонстрирует эубиотический эффект и обладает противовоспалительными свойствами. Учитывая разнообразные механизмы действия, рифаксимин-α положительным образом модулирует микробиоту кишечника.

Об авторах

С. К. Зырянов
ФГАОУ ВО «Российский университет дружбы народов»
Россия

Зырянов Сергей Кенсаринович - д. м. н., профессор, зав. кафедрой общей и клинической фармакологии

 Москва


Е. А. Байбулатова
ФГАОУ ВО «Российский университет дружбы народов»
Россия

Байбулатова Елена Александровна - к. м. н., ассистент кафедры общей и клинической фармакологии

Москва



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Для цитирования:


Зырянов С.К., Байбулатова Е.А. Рифаксимин-альфа и другие кристаллические формы рифаксимина: есть ли отличия? Антибиотики и Химиотерапия. 2020;65(7-8):52-62. https://doi.org/10.37489/0235-2990-2020-65-7-8-52-62

For citation:


Zyryanov S.K., Baybulatova E.A. Rifaximin-Alpha and Other Crystalline Forms of Rifaximin: Are There Any Differences? Antibiotics and Chemotherapy. 2020;65(7-8):52-62. (In Russ.) https://doi.org/10.37489/0235-2990-2020-65-7-8-52-62

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