The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals
A. U. Sabitov,
L. P. Larionov,
M. N. Dobrinskaya,
O. V. Ledyankina,
A. V. Osipenko,
I. E. Valamina,
E. V. Philippova,
I. M. Fatikhov Abstract
The paper presents the results of extended preclinical studies demonstrating the safety using the direct-acting antiviral drug Riamilovir in immature white rats. Riamilovir did not show any toxic effects on the growth of animals, their fertility, behavior, hematological and biochemical parameters, as well as morphology of visceral organs when used in a course. According to the results of the studies, Ramilovir can be recommended for multicenter clinical trials in adolescents and children of younger age groups.
About the Authors
A. U. Sabitov
Ural State Medical University
Russian Federation
Russian Federation
D. Sc. in Medicine, Professor, Head of the Department of Infectious Diseases and Clinical Immunology
3 Repina st., Ural State Medical University, Yekaterinburg, 620028
L. P. Larionov
Ural State Medical University
Russian Federation
Russian Federation
D. Sc. in Medicine, Professor at the Department of Pharmacology and Clinical Pharmacology
M. N. Dobrinskaya
Ural State Medical University
Russian Federation
Russian Federation
Ph. D. in Medicine, Assistant at the Department of Pharmacology and Clinical Pharmacology
O. V. Ledyankina
Ural State Medical University
Russian Federation
Russian Federation
Ph. D. in Pharmaceutical Sciences, Associate Professor, Department of Clinical Laboratory Diagnostics and Bacteriology
A. V. Osipenko
Ural State Medical University
Russian Federation
Russian Federation
D. Sc. in Medicine, Professor of the Department of Pathological Physiology
I. E. Valamina
Ural State Medical University
Russian Federation
Russian Federation
Ph. D. in Medicine, Associate Professor at the Department of Pathological Anatomy and Forensic Medicine, Ural State Medical University of the Ministry of Health of the Russian Federation; Head of the Histological Laboratory of the Central Scientific Research Laboratory
E. V. Philippova
Ural State Medical University
Russian Federation
Russian Federation
Ph. D. in Medicine, Assistant at the Department of Pharmacology and Clinical Pharmacology
I. M. Fatikhov
Ural State Medical University
Russian Federation
Russian Federation
Ph. D. in Medicine, Associate Professor at the Department of Pharmacology and Clinical Pharmacology
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For citations:
Sabitov A.U., Larionov L.P., Dobrinskaya M.N., Ledyankina O.V., Osipenko A.V., Valamina I.E., Philippova E.V., Fatikhov I.M. The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals. Antibiot Khimioter = Antibiotics and Chemotherapy. 2023;68(5-6):24-32. (In Russ.)
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