Polymer Complexes of Amikacin with Sulfur-Containing Polymers
https://doi.org/10.37489/0235-2990-2023-68-11-12-4-9
Abstract
Polymer complexes of amikacin based on two sulfonic polymers, dextran sulfonic acid and poly-2-acrylamido-2-methylpropane sulfonic acid, containing 25 and 33 wt % of the antibiotic, respectively, have been synthesized. Molecular weights and limiting binding capacities were determined for carrier polymers. The formation of polymer complexes was confirmed by IR and UV spectroscopy, as well as by GPC. The kinetics of amikacin release from complexes was investigated in water at 37°С. The resulting complexes exhibited high antibacterial activity, close to control, and weak antiviral activity.
About the Authors
A. Yu. Semina
Saint-Petersburg State Institute of Technology
Russian Federation
Russian Federation
Anastasiya Yu. Semina
Saint Petersburg
М. Yu. Smirnova
Institute of Macromolecular Compounds of the Russian Academy of Sciences
Russian Federation
Russian Federation
Marianna Yu. Smirnova — Ph. D. in Chemistry, Researcher at the Laboratory No. 2
Saint Petersburg
ResearcherID: N-3040-2016
М. V. Solovskij
Institute of Macromolecular Compounds of the Russian Academy of Sciences
Russian Federation
Russian Federation
Michail V. Solovskij
Saint Petersburg
ResearcherID: I-9072-2017
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Review
For citations:
Semina A.Yu., Smirnova М.Yu., Solovskij М.V. Polymer Complexes of Amikacin with Sulfur-Containing Polymers. Antibiot Khimioter = Antibiotics and Chemotherapy. 2023;68(11-12):4-9. (In Russ.) https://doi.org/10.37489/0235-2990-2023-68-11-12-4-9
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