Analysis of Spectral Characteristics of Certain Polyene Antibiotics in the Presence of Dmso and Cholesterol
https://doi.org/10.37489/0235-2990-2023-68-11-12-10-18
Abstract
This work presents ultraviolet (UV) spectra of various concentrations of polyene antibiotics. The spectra of Levorin and Amphotericin B differ in three main absorption maxima. The maximum absorption spectra of antibiotics vary in the range of 370–430 nm. UV absorption spectra reflect the characteristic spectrum of polyenes belonging to this class. Amphotericin B and Levorin in combination with cholesterol lower the maximum of the UV absorption spectra. Analysis of the obtained results shows that cholesterol molecules, combining with double-bond systems of Amphotericin B and Levorin, gradually reduce the maximum absorption of UV spectra, which creates opportunities for their more active use in various fields of biomedicine.
About the Authors
G. H. Sultanova
Institute of Botany of the Ministry of Science and Education of the Republic of Azerbaijan
Azerbaijan
Azerbaijan
Gulnar Hajibek kyzy Sultanova — Ph. D. in Biology, Associate Professor, Leading Researcher
Baku
T. J. Pashazade
Institute of Botany of the Ministry of Science and Education of the Republic of Azerbaijan
Azerbaijan
Azerbaijan
Pashazade Turkan Joshgun gyzy — graduate student
Baku
Kh. M. Kasumov
Institute of Botany of the Ministry of Science and Education of the Republic of Azerbaijan
Azerbaijan
Azerbaijan
Khalil M. Kasumov — D.Sc. in Biology, Professor, Corresponding Member of the ANAS
Baku
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Review
For citations:
Sultanova G.H., Pashazade T.J., Kasumov Kh.M. Analysis of Spectral Characteristics of Certain Polyene Antibiotics in the Presence of Dmso and Cholesterol. Antibiot Khimioter = Antibiotics and Chemotherapy. 2023;68(11-12):10-18. (In Russ.) https://doi.org/10.37489/0235-2990-2023-68-11-12-10-18
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