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Tamara Iosifovna Balezina: The Story of the Woman Who Discovered Soviet Penicillin

https://doi.org/10.37489/0235-2990-2025-70-11-12-100-109

EDN: BIWVSB

Abstract

Behind great discoveries there are always people whose lives are pushed into the background, yet they can inspire new generations to new achievements. One such person is Tamara Iosifovna Balezina, who discovered the Soviet penicillin and interferon; however, her contribution to science is little known. In this article her life and previously unknown details of the discovery of the Soviet penicillin are described based on the surviving sources, as well as on the information from the archive of the Balezin family, kindly provided by the son of Tamara Iosifovna to the author. The discovery that was made during the hard days of the Great Patriotic War (World War II). The article is accompanied by the unique photographs and documents, published for the first time, as well as by the only surviving image of the culture of the fungus Penicillium crustosum collected from the air of bomb shelter located in a residential building.

About the Author

V. A. Gorshkov-Cantacuzene
Russian Medical Academy of Continuous Professional Education
Russian Federation

Vladimir A. Gorshkov-Cantacuzene — Physician-bacteriologist, Senior Lectirer at the Z.V. Yermolyeva department of medical microbiology, Russian Medical Academy of Continuous Professional Education.

Moscow


Competing Interests:

None



References

1. Chigrinov S. N., Mironin A. V., Sobainov V. D., Teterin V. V., Tumanov A. S. Vklad sovetskih voennih uchenih v razrabotku promishlennih tehnologii proizvodstva pervih otechestvennih antibiotokov (penicllina I streptomicina). Vestnik Voisk RHB Zashiti. 2023; 7 (1): 82–92. doi: https://doi.org/10.35825/2587-5728-2023-7-1-82-92 (in Russian)

2. Blinkova L. P. Z. V. Yermolyeva — vidayshiis’a microbiology, sozdatel’ otechestvennogo penicillin i drugih antibacterial’nih preparatov. ZhMEI. 2019; 96 (2): 119–124 (in Russian)

3. Sherstneva E. V. Istoriya sozdaniya sovetskogo penicillin: vimisel i fakti. Problemi Social’noi Gigieni, Zdravoohraneniya i Istorii Midizini. 2019; 27 (4): 507–512. doi: https://doi.org/10.32687/0869-866X-2019-27-4-507-512. (in Russian)

4. Sherstneva E. V. Slovo o «sovetskom penicillin». Remedium. 2022; 26 (3); 276–282. doi: https://doi.org/10.32687/1561-5936-2022-26-3-276-282. (in Russian)

5. Avtobiografiya T. I. Balezinoi ot 28 dekabrya 1966 goda. 2. Arkhiv A. S. Balezina. (in Russian)

6. Svidetelstvo o brake II-А № 829680 ot 10 avgusta 1951 goda. Povtornoe. (in Russian)

7. Uchenie MPGU: Balezin Stepan Aleksandrovich. https://mpgu.su/scientists/balezin-stepan-afanasevich/ (in Russian)

8. Trudovaya knizhka Balezinoi T. I. Podlinnik]. Khranitsya v FGBUK «Gosudarstvennyj central'nyj muzej sovremennoj istorii Rossii». GCMSIR. F 479. GIK 48575/7. (in Russian)

9. Balezina T. I. K istorii otkratiya otechestvennogo penicillina. Antibiot Khimioter = Antibiotics and Chemotherapy. 1994; 39 (1): 29–32. (in Russian)

10. Balezina T. I. Zabitoe imya velikoi zhenshini. Avtorizovannaya mashinopis’. Arkhiv A. S. Balezina. (in Russian)

11. Fleming A. On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzæ. Br J Exp Pathol. 1929; 10 (3): 226–236.

12. Yermolyeva Z. V. Penicillin. Moscow: Narkomzdrav, Gos. izd-vo med. lit., Medgiz, 1946; 153. (in Russian)

13. Zlepko A. V., Skakovskii M. N., Sukacheva O. V. Vklad Z. V. Yermolyevoi v predotvrachenie epidemii choleri na Stalingradskom fronte v godi Velikoi Otechestvennoi voini. Zdorov’e Naseleniya i Sreda Obitaniya. 2017; 4 (288): 4–6 (in Russian)

14. Balezina T. I. Kak eto nachinalos’ ili istoriya sovetskogo penicillin. Avtorizovannaya machinopis’. 5. Arkhiv A. S. Balezina. (in Russian)

15. Golonzko R. A. Materiali k istorii evakuacionnogo gostitalya # 5004 Moscovskago gorodskogo otdela zdravoohraneniya 1941–1944 g.g. Avtorizovannaya machinopis. Khranitsya v GBU «CGA Moskvy». F. R-552. D. 6. (in Russian)

16. Yermolyeva Z. V. Penicillin-crustozin. Nauka i Zhizn’. 1967; 10: 118–122. (in Russian)

17. Balezina T. I. Poluchenie, issledovanie i klinicheskoe primenenie penicillin. Diss. … kandidata medicinskih nauk. Moskva, 1944. Khranitsya v FGBUK «Gosudarstvennyj central'nyj muzej sovremennoj istorii Rossii». GCMSIR. F 479. GIK 48575/4. (in Russian)

18. Mekshun E. I na kamnyah rastut… Farmacevticheskii vestnik. 2014; 19 (764). https://pharmvestnik.ru/articles/i-na-kamnjax-rastut.html (in Russian)

19. Istoriya Filiala Voenno-medicinskoi akademii v g. Moskve. https://filial-vmeda.ru/information/history.html (in Russian)

20. Yermolyeva Z. V. Antibiotiki, interferon, bacterial’nie polisaharidi. Moscow: Medicina, 1965; 382. (in Russian)

21. Yermolyeva Z. V., Furer N. M., Balezina T. I., Fadeeva L. L., Mecler L. B. Profilacticheskoe deistvie interferona na respiratornae virusi v ekperimente. Tezisi dokl. «Problemi Grippa», 1961; 175. (in Russian)

22. Yermolyeva Z. V., Furer N. M., Balezina T. I. Protivovirusnii preparat interferon. Antibiotiki. 1961. 3: 196–200 (in Russian)

23. The Nobel cause. The Lancet Infection Diseases. 2005; 5 (11): 665. doi: 10.1016/S1473-3099(05)70245-0.

24. Aleksandr Stepanovich Balezin: vazhnee sem’ya. https://hist.uniyar.ac.ru/news/aleksandr-stepanovich-balezin-vazhnee-semya/ (in Russian)


Review

For citations:


Gorshkov-Cantacuzene VA. Tamara Iosifovna Balezina: The Story of the Woman Who Discovered Soviet Penicillin. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(11-12):100-109. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-11-12-100-109. EDN: BIWVSB

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ISSN 0235-2990 (Print)