Screening of Antimicrobial Activity of Recombinant Proteins from Limosilactobacillus reuteri

Recombinant proteins from lactobacilli were obtained in purified soluble form. These proteins were subsequently screened for activity against a range of pathogenic microorganisms. Ribonucleoside hydrolase C (RihC) and cysteine synthase A (CysK) were shown to exhibit activity against biofilms of certain ESKAPE microorganisms. RihC also exhibited synergistic activity with certain antibiotics. In some cases, protease M23 has demonstrated intrinsic activity against pathogenic microorganisms, as well as synergism with a number of antibacterial drugs — meropenem, aztreonam, and ceftazidime.

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