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Influence of Natural Complex Compounds with Hipolipidemic Activity on Expression of Bacteria Virulence Factors

Abstract

Natural complex compounds with hipolipidemic activity, having considerable inhibitory effect on expression of bacteria virulence factors were isolated. Inhibitory properties of the compounds with respect to pyocyanine and protease formation, as well as their influence on the quorum sensing mechanism in Chromobacterium violacium were shown.

About the Authors

V. Yu. Gotovtseva
Московский государственный университет инженерной экологии
Russian Federation


N. E. Grammatikova
Государственный научный центр антибиотиков
Russian Federation


M. V. Bibikova
Государственный научный центр антибиотиков
Russian Federation


A. V. Katlinsky
НПО «Микроген»
Russian Federation


References

1. Хохлов А. С, Овчинников Ю.А. Химические регуляторы биологических процессов. М.: Знание, 1969; 142.

2. Eberl L. N-Acyl homoserinelactone-mediated gene regulation in gramnegative bacteria. Syst Appl Microbiol 1999; 22: 493-506.

3. Waters C. M., Bassler B. L. Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 2005; 21: 319-346.

4. Hentzer M. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 2003; 22: 3803-3815.

5. Smith K.M., Bu Y., Suga H. Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs. Chem Biol 2003; 10: 81-89.

6. Andy Schaber K. et al. Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa. Med Microbiol 2004; 53: 841-853.

7. Чмель Я.В., Бибикова М.В., Спиридонова И.А. и др. Скрининг природных соединений с гиполипидемической активностью. Антибиотики и химеотер. 2004; 8-9: 8-12.

8. Чмель Я.В., Бибикова М.В., Спиридонова И.А. и др. Изучение в опытах in vivo отобранных биологически активных веществ, обладающих гиполипидемическими свойствами. Успехи медицинской микологии: Мат. Всероссийского конгресса по медицинской микологии. М: 2004; 3: 138-139.

9. Бибикова М.В., Селехова Г.H., Востров С.Н. и др. Оптимизация состава ферментационной среды для выделения продуцентов антибиотиков из микромоноспор. Антибиотики. 1981; 12: 899-904.

10. McClean K.N., Winson M.K., Fish L. et al. Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology 1997; 143: 3703-3711.

11. Latifi A., Winson M.K., Foglino M. et al. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1. Mol Microbiol 1995; 17: 333-343.

12. Kessler E., Safrin M., Abrams W.R. et al. Inhibitors and specificity of Pseudomonas aeruginosaLasA. JBC 1997; 272: 15: 9884-9889.

13. Николаев Ю.А., Паников H.С. Внеклеточная протеаза как регулятор обратимой адгезии Pseudomonas fluorescens. Микробиология 2002; 71: 5: 629-634.


Review

For citations:


Gotovtseva V.Yu., Grammatikova N.E., Bibikova M.V., Katlinsky A.V. Influence of Natural Complex Compounds with Hipolipidemic Activity on Expression of Bacteria Virulence Factors. Antibiot Khimioter = Antibiotics and Chemotherapy. 2011;56(7-8):3-6. (In Russ.)

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ISSN 0235-2990 (Print)