Efficacy and Tolerance of Rezonizate in Complex with Fluoroquinolones or Mycobutin on a Model of Experimental Murine Tuberculosis
Abstract
The efficacy of rezonizate, a novel antituberculosis drug, in combination with fluoroquinolones or mycobutin was studied in experiments on mice infected with Mycobacterium tuberculosis. By the pathomorphological and microbiological criteria, the highest therapeutic effect was observed when rezonizate was used in combination with levofloxacin, the lowest effect was produced by rezonizate combination with gatifloxacin.
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The authors declares that there is no conflict of interest.
Article info:
Date submitted: 13.05.2020
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About the Authors
G. B. Sokolova
НИИ фтизиопульмонологии Первого МГМУ им. И.М. Сеченова
Russian Federation
B. M. Maliev
НИИ фтизиопульмонологии Первого МГМУ им. И.М. Сеченова
Russian Federation
G. N. Mozhokina
НИИ фтизиопульмонологии Первого МГМУ им. И.М. Сеченова
Russian Federation
N. A. Elistratova
НИИ фтизиопульмонологии Первого МГМУ им. И.М. Сеченова
Russian Federation
I. P. Solovyeva
НИИ фтизиопульмонологии Первого МГМУ им. И.М. Сеченова
Russian Federation
S. E. Bugaenko
НИИ фтизиопульмонологии Первого МГМУ им. И.М. Сеченова
Russian Federation
References
1. Борисов С.E., Соколова Г.Б. Этиотропное лечение туберкулеза при лекарственно-устойчивых микобактериях туберкулеза. Взгляды и рекомендации международных организаций. / Consilium medicum. 2001; 12: 595-602.
2. Соколова Г.Б., Лазарева Я.В., Киртаева О.В. и др. Резонизат и циклосерин в комплексной терапии лекарственно-реистентного туберкулёза (сравнительное исследование) / Антибиотики и химиотерапия. 2008; 11-12: 25-28.
For citations:
Sokolova G.B.,
Maliev B.M.,
Mozhokina G.N.,
Elistratova N.A.,
Solovyeva I.P.,
Bugaenko S.E.
Efficacy and Tolerance of Rezonizate in Complex with Fluoroquinolones or Mycobutin on a Model of Experimental Murine Tuberculosis. Antibiot Khimioter = Antibiotics and Chemotherapy. 2011;56(7-8):22-26.
(In Russ.)
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