INVESTIGATION OF STRUCTURAL CHARACTERISTICS OF INITIAL SUBSTANCES OF IBUPROFEN AND MICRONIZATION IMPACT
Abstract
Structural characteristics of ibuprofen substances manufactured by different firms and the impact of micronization on them were compared. The study showed that the use of X-ray diffraction methods was necessary for certification of medicinal (crystalline) since only such methods provided information on the substance crystal structure, the molecular state and polymorphous forms.
About the Authors
N. N. Lobanov
Russian University of People Friendship
Russian Federation
Russian Federation
N. S. Knuchua
Russian University of People Friendship
Russian Federation
Russian Federation
YU. A. Obidenko
Russian University of People Friendship
Russian Federation
Russian Federation
R. A. Abramovich
Russian University of People Friendship
Russian Federation
Russian Federation
References
1. Stone K. H., Lapidus S. H., Stephens P. W. J Appl Cryst 2009; 42: 3: 385-391.
2. Derollez P., Dudognon E., Affouard F., Danède F., Correia N. T., Descamps M. Ab initio structure determination of phase II of racemic ibuprofen by X-ray powder diffraction. Acta Cryst 2010; B66: 1: 76-80.
3. Hansen L. K., Perlovich G. L., Bauer-Brandl A. Redetermination and H-atom Refinement of (S)-(+)-Ibuprofen. corrigendum. Acta Cryst 2006; E62: 7: e17-e18.
4. Комплекс программ PDWin для рентнгендифракционных исследований (2010), НПП «Буревестник», ОАО.
5. McConnell J. F. Cryst Struct Commun 1974; 3: 73-75.
6. Gong P. Polytechnic Inst. of Brooklyn, NY, USA, 1981.
Review
For citations:
Lobanov N.N., Knuchua N.S., Obidenko Yu.A., Abramovich R.A. INVESTIGATION OF STRUCTURAL CHARACTERISTICS OF INITIAL SUBSTANCES OF IBUPROFEN AND MICRONIZATION IMPACT. Antibiot Khimioter = Antibiotics and Chemotherapy. 2012;57(3-4):3-8. (In Russ.)
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