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Protective Activity of Aqueous Extracts from Higher Mushrooms Against Herpes sipmlex Virus Type-2 on Albino Mice Model

Abstract

Toxicity and antiviral activity of aqueous extracts from higher mushrooms such as Lentinula edodes (Berk.) Pegler (shiitake), Pleurotus ostreatus (Jacq.) P. Kumm. (oyster), Inonotus obliquus (Ach. ex Pers.) Pilat (chaga), Hydnellum compactum (Pers.) P. Karst. (compact tooth) were studied. In doses of 0.8 to 4.0 mg (dry weight) per mouse administered orally or intraperitoneally the extracts showed no acute toxicity. When the dose of the chaga extract was increased to 20 mg per mouse, a half of the animals died. Intraperitoneal administration of the aqueous extracts in a dose of 0.4-2 mg per mouse prior to the contamination by a single LD50 of Herpes simplex type 2 provided 100-percent survival of the animals exposed to the Lentinula edodes or Pleurotus ostreatus extracts and 90-percent survival of the animals exposed to the Inonotus obliquus or Hydnellum compactum extracts.

About the Authors

I. A. Razumov
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences; State Research Center of Virology and Biotechnology Vector
Russian Federation


E. I. Kazachinskaya
State Research Center of Virology and Biotechnology Vector
Russian Federation


L. I. Puchkova
State Research Center of Virology and Biotechnology Vector
Russian Federation


T. A. Kosogova
State Research Center of Virology and Biotechnology Vector
Russian Federation


I. A. Gorbunova
Central Siberian Botanical Gardens, Siberian Branch of the Russian Academy of Sciences
Russian Federation


V. B. Loktev
State Research Center of Virology and Biotechnology Vector
Russian Federation


T. V. Teplyakova
State Research Center of Virology and Biotechnology Vector
Russian Federation


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Review

For citations:


Razumov I.A., Kazachinskaya E.I., Puchkova L.I., Kosogova T.A., Gorbunova I.A., Loktev V.B., Teplyakova T.V. Protective Activity of Aqueous Extracts from Higher Mushrooms Against Herpes sipmlex Virus Type-2 on Albino Mice Model. Antibiot Khimioter = Antibiotics and Chemotherapy. 2013;58(9-10):8-12. (In Russ.)

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ISSN 0235-2990 (Print)