Investigation of Prophylactic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice
Abstract
Prophylactic efficacy of Triazavirin against experimental Forest-Spring encephalitis was studied on albino mice vs. the active drug Ribavirin®. A significant increase of the animal lifespan in the test groups (from 4 to 5 days) and a statistically (р<0.05) valid decrease of the virus accumulation level in the target organ (the brain) were observed.
About the Authors
S. Ya. Loginova
Central Research Institute No. 48, Ministry of Defense of the Russian Federation
Russian Federation
Russian Federation
S. V. Borisevich
Central Research Institute No. 48, Ministry of Defense of the Russian Federation
Russian Federation
Russian Federation
V. L. Rusinov
B. N. Eltsin Ural State Technical University
Russian Federation
Russian Federation
U. N. Ulomsky
B. N. Eltsin Ural State Technical University
Russian Federation
Russian Federation
V. N. Charushin
B. N. Eltsin Ural State Technical University
Russian Federation
Russian Federation
O. N. Chupakhin
B. N. Eltsin Ural State Technical University
Russian Federation
Russian Federation
P. V. Sorokin
Ural Centre of Biopharmaceutical Technologies
Russian Federation
Russian Federation
References
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2. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ. М.: Минздрав РФ, 2012
3. Логинова С.Я., Борисевич С.В., Русинов В.Л., Уломский E.H., Чарушин В.Н., Чупахин О.Н. Оценка токсичности нового отечественного химиопрепарата триазавирин. Антибиотики и химиотер - 2012; 11-12: 8-10
Review
For citations:
Loginova SY, Borisevich SV, Rusinov VL, Ulomsky UN, Charushin VN, Chupakhin ON, Sorokin PV. Investigation of Prophylactic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2015;60(5-6):8. (In Russ.)
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