Assessment of Antitumor Effect of Submerged Culture of Ophiocordyceps sinensis and Cordyceps militaris
Abstract
Ophiocordyceps sinensis and Cordyceps militaris metabolites showed a high potential in the treatment of tumors as well as some other diseases. Antitumor properties of O.sinensis and C.militaris submerged mycelium were investigated. It was found that the O.sinensis dry biomass in a dose of 50 mg/kg administered once a day to the mice with subcutaneously inoculated P388 lymp-holeucosis lowered the tumor growth by 65% vs. 54% for the C.militaris dry biomass. The water extract of O.sinensis submerged culture however accelerated the growth of the Р388 lympholeucosis tumor node in the mice almost two times, compared to the control. A greater caution in using this fungus as a source of biologically active substances is required since unwanted tumor-stimulating effects can arise.
About the Authors
A. V. Avtonomova
G.F. Gause Research Institute of New Antibiotics
Russian Federation
Russian Federation
L. M. Krasnopolkaya
G.F. Gause Research Institute of New Antibiotics
Russian Federation
Russian Federation
M. I. Shuktueva
G.F. Gause Research Institute of New Antibiotics
Russian Federation
Russian Federation
E. B. Isakova
G.F. Gause Research Institute of New Antibiotics
Russian Federation
Russian Federation
V. M. Bukhman
N.N. Blokhin Russian Scientific Cancer Centre
Russian Federation
Russian Federation
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Review
For citations:
Avtonomova A.V., Krasnopolkaya L.M., Shuktueva M.I., Isakova E.B., Bukhman V.M. Assessment of Antitumor Effect of Submerged Culture of Ophiocordyceps sinensis and Cordyceps militaris. Antibiot Khimioter = Antibiotics and Chemotherapy. 2015;60(7-8):14-17. (In Russ.)
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