Experimental Substantiation of Taurine Use in Prophylaxis of Isoniazid-Induced Neurotoxic Reactions
Abstract
The effect of taurine and vitamin B6 on the clinical process and mortality of experimental mice due to isoniazid was studied in an acute test. The use of taurine lowered the toxic effect of isoniazid, evident from delayed covulsions, their shorter time, rarer repeat and lower mortality of the animals due to tonoclonic spasm. The most significant decrease of the neurotoxic effect of isoniazid was observed with the use of taurine in a dose of 255 mg/kg. When taurine in the dose of 255 mg/kg was used in combination with vitamin B6 in prophylactic doses of 1.3 or 3.9 mg/kg, no death of the mice due to isoniazid in the acute test was recorded.
About the Authors
G. N. Mozhokina
Research Institute of Phthisiopulmonology, I.M. Sechenov 1st Moscow State Medical University
Russian Federation
Russian Federation
N. A. Elistratova
Research Institute of Phthisiopulmonology, I.M. Sechenov 1st Moscow State Medical University
Russian Federation
Russian Federation
References
1. Соколова Г.Б. Индивидуализированная химиотерапия туберкулёза лёгких (экспериментально-клинические исследования). Дисс. ... в виде научного доклада на соискание ученой степени д.м.н. М.: 2000; 67
2. Энциклопедия лекарств. РЛС-2008. 2007; 342-343
3. Соколова Г.Б, Зия A.B., Румянцев В.Б. О влиянии отечественного транквилизатора фенозепама для профилактики и лечения «острой» токсичности изониазида. Проблемы туберкулёза 1980; 3: 59-62
4. Соколова Г.Б., Куничан А.Д., Зия A.B., Можокина Т.Н. Эффективные и щадящие режимы химиотерапии больных туберкулёзом лёгких. Пособие для врачей-фтизиатров. М.: 1998; 17
5. Olive M.F. Interactions between taurine and ethanol in the central nervous system. Amino Acids 2002; 23: 4: 345-357
6. Звягинцева Т.В., Киричек Л.Т, Кратенко А.С. Коррекция таурином состояния ЦНС, надпочечников и фагоцитарной активности при экспериментальном стрессе. Фармакологія та лікарська токсикологія 2008; 5-6: 6-7: 58-63
7. Caletti G., Olguins D.B., Pedrollo E.F., Barros H.M., Gomez R. Antidepressant effect of taurine in diabetic rats. Amino Acids 2012 Oct; 43: 4: 1525-1533.
8. Toyoda A., Iio W. Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats. Adv Exp Med Biol 2013; 775: 29-43.
9. Paula-Lima A.C., De Felice F.G., Brito-Moreira J., Ferreira S.T. Activation of gaba(a) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons. Neuropharmacology 2005 Dec; 49: 8: 1140-1148.
10. Reza Heidari et al. Сytoprotective effects of taurine against toxicity induced by isoniazid and hydrazine in isolated rat hepatocytes; Arh Hig Rada Toksikol 2013; 64: 201-210.
11. Способ снижения непереносимости противотуберкулёзных препаратов (http://www.findpatent.ru/patent/241/2412701.html)
Review
For citations:
Mozhokina G.N., Elistratova N.A. Experimental Substantiation of Taurine Use in Prophylaxis of Isoniazid-Induced Neurotoxic Reactions. Antibiot Khimioter = Antibiotics and Chemotherapy. 2016;61(3-4):19-22. (In Russ.)
Views:
570
Email this article 