Potential Possibilities of Monitoring the Procalcitonin Concentration During Antibacterial Therapy of Lower Respiratory Tract Infections
Abstract
The growing level of resistance of microorganisms requires a critical reduction in cases of unreasonable use of antibiotics and a reduction in the overall duration of antibiotic therapy. Controlled clinical trials conducted in recent years have confirmed the high effectiveness of the use of the procalcitonin test (B-R-A-H-M-S PCT™) in reducing the occurrence of unjustified prescribing of antibiotic therapy and reducing its duration.In this regard, procalcitonin test promotes the personalization of approaches to antibiotic therapy. It is possible to significantly reduce the frequency of empirical antibiotic therapy in low-risk situations (bronchitis, exacerbation of COPD) by determining the level of procalcitonin (B-R-A-H-M-S PCT™). Monitoring the concentration of procalcitonin allows shortening of the duration of antibiotic therapy in more severe clinical situations (pneumonia, sepsis).
About the Authors
N. B. Lazareva
I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
M. V. Zhuravleva
I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. B. Prokofiev
I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. V. Shikh
Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Lazareva N.B., Zhuravleva M.V., Prokofiev A.B., Shikh E.V. Potential Possibilities of Monitoring the Procalcitonin Concentration During Antibacterial Therapy of Lower Respiratory Tract Infections. Antibiot Khimioter = Antibiotics and Chemotherapy. 2018;63(1-2):32-37. (In Russ.)
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