Immunopathogenetic Disorders in Patients with Herpesvirus Infections
https://doi.org/10.37489/0235-2990-2020-65-9-10-28-31
Abstract
Immunological disorders were studied in 68 patients with herpesvirus infections (41 women and 27 men) aged 18 to 55 years. All patients were examined clinically, also laboratory tests were conducted during the period of exacerbation and clinical remission. Patients with herpesvirus infections showed a significant decrease in the relative number of CD3+, CD4+ T-lymphocytes and their subpopulations during exacerbation of herpes infection. A decrease in the content of CD 3+, CD4+ T-cells during exacerbation of the disease was associated with an increase in CD8+ T-lymphocytes. The immunoregulatory index also decreased. The relative number of CD19+ B cells significantly increased in the exacerbation stage. During the period of remission, the number of CD19+ lymphocytes decreased, remaining above the normal range in patients with severe disease. Studies have shown that patients with herpesvirus infections have immunopathological disorders both during the relapse period and during the remission period, which must be taken into account when treating these patients.
About the Authors
Z. A. Kambachokova
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
M. A. Khamurzova
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
R. M. Aramisova
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
L. M. Timmoeva
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
Zh. L. Shogenova
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
A. G. Shokueva
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
T. B. Kipkeeva
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
M. Kh. Dadaev
Kabardino'Balkarian State University named after H. M. Berbekov
Russian Federation
Nalchik
Russian Federation
Nalchik
References
1. Isakov V.A., Arkhipova E.I., Isakov D.V. Gerpesvirusnye infektsii cheloveka: rukovodstvo dlya vrachej. SPb.: 2013. [in Russian]
2. Nagoev B.S., Kambachokova Z.A. Tsitokinovyj status u bol-nykh gerpesvirusnymi infektsiyami. Infektsionnye bolezni. 2011; 11(1): 19–23. [in Russian]
3. Schiffer J.T., Abu-Raddad L, Mark K.E. et al. Frequent Release of LowAmounts of Herpes Simplex Virus From Neurons: Results of a Mathemati-cal Model. Sci Transl Med 2009 Nov 18; l (7): 178–184.
4. Khryanin A.A. Gerpes pod podushkoj. Rasprostranennost- virusa prostogo gerpesa v rossijskoj populyatsii: mnogoletnij monitoring. Status Praesens 2013; 6 (17): 69–76.
5. Andropova V.L. Sovremennaya etiotropnaya khimioterapiya gerpesvirusnykh infektsij: dostizheniya, novye tendentsii i perspektivy. Al-fagerpesvirusy (chast- 1). Voprosy Virusologii 2018; 63 (3): 106–114.
6. De Donno A., Kuhdari P., Guido M., Rota M.C., Bella A., Brignole G. et al. Has VZV epidemiology changed in Italy? Results of a seroprevalence study. Hum Vaccin Immunother 2017; 13 (2): 385–390.
7. Perez-Farinos N., Garcia-Comas L., Ramirez-Fernandez R., Sanz J.C., Barranco D., Garcia-Fernandez C. et al. Seroprevalence of antibodies to varicella-zoster virus in Madrid (Spain) in the absence of vaccination. Cent Eur J Public Health 2008; 16 (1): 41–44.
8. Polovtseva T. V., Karazhas N.V., Kalugina M.Yu., Mamedova E.A., Finogenova N.A., Lavrent-eva I.N. Diagnosis of herpes virus infection in young children. Detskie infektsii 2012; 11 (2): 51–53. [in Russian]
9. Sizhazheva A.M., Sizhazheva A.L. Laboratory diagnosis of herpes virus infection by PCR. Innovatsionnaya Nauka 2015; 12 (2): 286–289. [in Russian]
10. Кравченко Л.В. Клинико-патогенетические аспекты герпесвирусных инфекций у детей первых месяцев жизни: Дис. ... д-ра мед. наук. Ростов-на-Дону. 2009.
11. Kambachokova Z.A. Pokazateli kletochnogo i gumoral-nogo immuniteta u bol-nykh gerpesvirusnymi infektsiyami. Vestnik Bashkortostana 2012; 3: 112–117. [in Russian]
12. Isakov V.A., Isakov D.V. Immunomodulyatory v terapii i profilaktike gerpesvirusnykh infektsij. Klinicheskaya Meditsina 2015; 93 (4): 16–24. [in Russian]
13. Isakov V.A., Isakov D.V. Patogenez i terapiya sotsial-no-znachimykh virusnykh infektsij. Klinicheskaya Farmakologiya i Terapiya 2014; 23 (1): 7–13. [in Russian]
14. Shul-zhenko A.E., Zujkova N.I., Shchubel-ko R.V. Retsidivirujyushchaya gerpesvirusnaya infektsiya: vozmozhnosti immunotropnoj terapii. Meditsinskoe obozrenie. Nauka i Praktika. 2015; 3 (3): 43–51. [in Russian]
15. Vikulov G.Kh. Immunologicheskie aspekty gerpesvirusnykh infektsij. Klinicheskaya Dermatologiya i Venerologiya 2015; 14 (5): 104–116. [in Russian]
16. Nagoev B.S., Kambachokova Z.A. Pokazateli kletochnogo immuniteta u bol-nykh gerpesvirusnymi infektsiyami. Vestnik Novykh Meditsinskikh Tekhnologij. 2011; 17 (3): 325–327. [in Russian]
Review
For citations:
Kambachokova Z.A., Khamurzova M.A., Aramisova R.M., Timmoeva L.M., Shogenova Zh.L., Shokueva A.G., Kipkeeva T.B., Dadaev M.Kh. Immunopathogenetic Disorders in Patients with Herpesvirus Infections. Antibiot Khimioter = Antibiotics and Chemotherapy. 2020;65(9-10):28-31. (In Russ.) https://doi.org/10.37489/0235-2990-2020-65-9-10-28-31
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