The Study of the Dynamics and the Level of Accumulation of Interferon in the Serum of Laboratory Animals

Studies have shown that high-molecular inducers of interferon Larigan®, Ridostin®, and Rifastin cause «early» interferon production which amounts to maximum 3 hours after injection. Re-introduction of interferon inducers with an interval of 3 days does not cause the inhibition of interferon synthesis, i.e. refractoriness is not observed. Oral administration of a low molecular weight interferon inducer Arbidol® also stimulates the synthesis of endogenous interferon in the blood serum of rabbits, but in much lower concentrations. Reaferon^® when administered intramuscularly to primates in therapeutically effective concentrations is detected in the serum of monkeys 6 hours after application. Reaferon® is not detected in the serum of monkeys after oral administration. It was also impossible to identify the drug after intramuscular administration in rabbits, even at high doses.

vesicular stomatitis virus, cell culture, Larifan®, Rifastin, Ridostin®, Reaferon®, Arbidol®, green monkeys, cotton rats, rabbits