Antiviral Properties of Aqueous and Ethanol Extracts of Shaggy Mane (Coprinus comatus) Against Influenza Virus in in vitro and in vivo Experiments
Abstract
The chemical composition and anti-influenza activity of aqueous and ethanol extracts obtained from fruit bodies of Coprinus comatus (O.F. Müll.) Pers. (Shaggy mane) were studied. The antiviral activity of both mushroom extracts against influenza virus A/Aichi/2/68(H3N2) and A/chicken/Kurgan/05/2005(H5N1) was revealed for continuous culture of MDCK cells (index suppression of reproduction in the cells of both strains was from 2,0 to 4,7 lg). Dose dependency of antiviral activity of mushroom extracts was shown in in vitro experiments. The significant protective effect of both Coprinus comatus extracts on the influence on the survival rate of mice infected with influenza virus A/H3N2 in the treatment and prevention scheme was revealed in in vivo experiments.
About the Authors
E. I. Filippova
State Research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
O. Yu. Mazurkov
State Research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
I. A. Gorbunova
Central Siberian Botanical Garden SB RAS
Russian Federation
Russian Federation
N. E. Kostina
Institute of Cytology and Genetis of Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
N. A. Mazurkova
State Research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
Review
For citations:
Filippova E.I., Mazurkov O.Yu., Gorbunova I.A., Kostina N.E., Mazurkova N.A. Antiviral Properties of Aqueous and Ethanol Extracts of Shaggy Mane (Coprinus comatus) Against Influenza Virus in in vitro and in vivo Experiments. Antibiot Khimioter = Antibiotics and Chemotherapy. 2018;63(11-12):8-11. (In Russ.)
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