Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line
https://doi.org/10.37489/0235-2990-2023-68-5-6-33-38
Abstract
The paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice. The cytogenetic activity and protective properties assessment was carried out using the chromosome aberration analysis in metaphase cells. Etoposide was tested at a concentration of 15 and 3 mg/kg and aspirin — at a concentration of 25 mg/kg of the animal. The results of metaphase analysis showed that etoposide exhibits cytogenetic toxicity in both doses, and aspirin exhibits protective properties against the toxicity of etoposide at a concentration of 15 mg/kg. The results of chromosome analysis regarding the protective properties of aspirin against etoposide at a concentration of 3 mg/kg are ambiguous and require further experiments.
About the Authors
O. N. Antosyuk
Ural Federal University named after the first President of Russia B. N. Yeltsin
Russian Federation
Competing Interests:
Russian Federation
Ph. D. in Biology, Associate Professor
19 Mira st,, Ural Federal University named after the first President of Russia B. N.Yeltsin, Yekaterinburg, 620002
Competing Interests:
Авторы сообщают об отсутствии конфликта интересов.
A. V. Gorskaya
Ural Federal University named after the first President of Russia B. N. Yeltsin
Russian Federation
Competing Interests:
Russian Federation
student
Competing Interests:
Авторы сообщают об отсутствии конфликта интересов.
D. V. Petrovskii
Federal Research Center «Institute of Cytology and Genetics» of the Siberian Branch of the Russian Academy of Sciences; Institute of Systematics and Ecology of Animals of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Competing Interests:
Russian Federation
Ph. D. in Biology, chief expert Institute of Systematics and Ecology of Animals of the Siberian Branch of the Russian Academy of Sciences
Competing Interests:
Авторы сообщают об отсутствии конфликта интересов.
T. D. Dubatolova
Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Competing Interests:
Russian Federation
Researcher
Competing Interests:
Авторы сообщают об отсутствии конфликта интересов.
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For citations:
Antosyuk O.N., Gorskaya A.V., Petrovskii D.V., Dubatolova T.D. Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line. Antibiot Khimioter = Antibiotics and Chemotherapy. 2023;68(5-6):33-38. (In Russ.) https://doi.org/10.37489/0235-2990-2023-68-5-6-33-38
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