Efficacy Evaluation of Complex Therapy of Perinatal Diseases in Extremely Low Birth Weight Infants

Abstract

Objective: to establish the role of antihypoxant/antioxidant therapy in prevention of adverse perinatal outcomes in premature infants with extremely low body mass using mathematical modeling as a basis. A catamnestic study of the complex therapy outcomes in 447 extremely low birth weight newborns who received treatment at the 2^nd stage of nursing was carried out using the data from patients' anamnesis for 2010-2015. Results: based on the mathematical modeling of the outcomes with a combination of the used volume of drugs, we predicted a 20% decrease in the number of nosological forms in 100% application of cytoflavin in the complex therapy of extremely low birth weight infants. Conclusions: the obtained results confirm the possibility of inclusion of drugs with an antihypoxant/antioxidant mechanism of action in the complex therapy of neonatal conditions in extremely low birth weight infants.