The Case of Congenital Combined Immunodeficiency with Severe Atopy: The Importance of Early Diagnosis and Features of Therapeutic Strategies
https://doi.org/10.37489/0235-2990-2024-69-9-10-56-60
EDN: HNYAYH
Abstract
The article describes a case of congenital combined immunodeficiency with severe atopy – deficiency of the cytogenesis regulator (DOCK8) The article examines modern ideas about the role of DOCK8 protein in ensuring the basic functions of the immune system, the consequences of loss of function of DOCK8 protein, epidemiology, clinical manifestations, modern principles of diagnosis and treatment of DOCK8 deficiency.
About the Authors
E. N. Serebryakova
South Ural State Medical University of the Ministry of Health of the Russian Federation ; Chelyabinsk Regional Children's Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Elena N. Serebryakova — D. Sc. in Medicine, Associate Professor, Professor of the Department of Hospital Pediatrics
ResearcherID: ABG-8330-2021 ; Scopus Author ID: 36020648000
Chelyabinsk
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов.
T. V. Shilova
South Ural State Medical University of the Ministry of Health of the Russian Federation ; Chelyabinsk Regional Children's Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Tatiana V. Shilova
Scopus Author ID: 57211799427
Chelyabinsk
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов.
A. S. Kozhevnikov
South Ural State Medical University of the Ministry of Health of the Russian Federation ; Chelyabinsk Regional Children's Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Artem S. Kozhevnikov
ResearcherID: RID72103 ; Scopus Author ID: 58103491300
Chelyabinsk
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов.
A. M. Razzhivin
South Ural State Medical University of the Ministry of Health of the Russian Federation ; Chelyabinsk Regional Children's Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Artem M. Razzhivin
ResearcherID: LIF-4379-2024
Chelyabinsk
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов.
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Review
For citations:
Serebryakova E.N., Shilova T.V., Kozhevnikov A.S., Razzhivin A.M. The Case of Congenital Combined Immunodeficiency with Severe Atopy: The Importance of Early Diagnosis and Features of Therapeutic Strategies. Antibiot Khimioter = Antibiotics and Chemotherapy. 2024;69(9-10):56-60. (In Russ.) https://doi.org/10.37489/0235-2990-2024-69-9-10-56-60. EDN: HNYAYH
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