Influence of Liver Pathologies on the Development and Progression of Breast Cancer: Pathophysiological Mechanisms, Therapeutic Strategies and Prevention
https://doi.org/10.37489/0235-2990-2025-70-5-6-52-57
EDN: QYTJLE
Abstract
This article analyzes the relationship between liver pathologies and breast cancer (BC). We consider the pathophysiological mechanisms underlying this relationship, including the influence of non-alcoholic fatty liver disease (NAFLD), drug-induced liver injury (DILI), and estrogen metabolism disorders. Particular attention is paid to the molecular pathways that contribute to the development of BC against the background of liver pathologies. An overview of modern therapeutic and preventive strategies for women with identified liver pathologies, as well as for women with liver pathologies and the first signs of BC is presented. The article describes drugs with confirmed efficacy based on international studies, and also provides recommendations on diet and regimen that help improve the prognosis of survival.
About the Authors
A. S. Vologirov
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Aslan S. Valogirov — Associate Professor, Department of Normal and Pathological Anatomy, Medical Academy
Nalchik
L. A. Timmoeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Leila A. Temmoeva — D. Sc. in Medicine, Professor, Department of Pediatric Diseases, Obstetrics and Gynecology, Medical Academy
Nalchik
Z. A. Kambachokova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zareta A. Kambachokova — D. Sc. in Medicine, Professor at the Department of Hospital Therapy, Medical Academy
Nalchik
A. A. Kambachokova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Amina A. Kambachokova — 4th year student with a General Medicine major, Medical Academy
Nalchik
Z. Kh. Makhieva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zukhra Kh. Makhieva — 6th-year student, Specialty «General Medicine», Medical Academy
Nalchik
R. A. Mamedov
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Rinat A. Mamedov — 6th-year student of the «General Medicine» specialty
Nalchik
A. Kh. Betuganova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Alina Kh. Betuganova — 6th year student of the «General Medicine» specialty, Medical Academy
Nalchik
A. A. Zhakova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Adelina A. Zhakova — 6th year student of the «General Medicine» specialty, Medical Academy
Nalchik
Z. Kh. Gadieva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zulfiya Kh. Gadieva — 1st year resident in the specialty «Anesthesiology-resuscitation», Medical Academy
Nalchik
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Review
For citations:
Vologirov A.S., Timmoeva L.A., Kambachokova Z.A., Kambachokova A.A., Makhieva Z.Kh., Mamedov R.A., Betuganova A.Kh., Zhakova A.A., Gadieva Z.Kh. Influence of Liver Pathologies on the Development and Progression of Breast Cancer: Pathophysiological Mechanisms, Therapeutic Strategies and Prevention. Antibiot Khimioter = Antibiotics and Chemotherapy. :52-57. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-5-6-52-57. EDN: QYTJLE
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