Influence of Liver Pathologies on the Development and Progression of Breast Cancer: Pathophysiological Mechanisms, Therapeutic Strategies and Prevention
https://doi.org/10.37489/0235-2990-2025-70-5-6-52-57
EDN: QYTJLE
Abstract
This article analyzes the relationship between liver pathologies and breast cancer (BC). We consider the pathophysiological mechanisms underlying this relationship, including the influence of non-alcoholic fatty liver disease (NAFLD), drug-induced liver injury (DILI), and estrogen metabolism disorders. Particular attention is paid to the molecular pathways that contribute to the development of BC against the background of liver pathologies. An overview of modern therapeutic and preventive strategies for women with identified liver pathologies, as well as for women with liver pathologies and the first signs of BC is presented. The article describes drugs with confirmed efficacy based on international studies, and also provides recommendations on diet and regimen that help improve the prognosis of survival.
About the Authors
A. A. Kambachokova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Amina A. Kambachokova, 4th year student with a General Medicine major
Medical Academy
Nalchik
A. S. Vologirov
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Aslan S. Vologirov, Associate Professor
Medical Academy; Department of Normal and Pathological Anatomy
Nalchik
L. A. Temmoeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Leila A. Temmoeva, D. Sc. in Medicine, Professor
Medical Academy; Department of Pediatric Diseases, Obstetrics and Gynecology
Nalchik
Z. A. Kambachokova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zareta A. Kambachokova, D. Sc. in Medicine, Professor
Medical Academy; Department of Hospital Therapy
Nalchik
Z. Kh. Makhieva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zuhra Kh. Makhieva, 6th-year student, Specialty «General Medicine»
Medical Academy
Nalchik
R. A. Mamedov
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Rinat A. Mamedov, 6th-year student of the «General Medicine» specialty
Medical Academy
Nalchik
A. Kh. Betuganova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Alina Kh. Betuganova, 6th year student of the «General Medicine» specialty
Medical Academy
Nalchik
A. A. Zhakova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Adelina A. Zhakova, 6th year student of the «General Medicine» specialty
Medical Academy
Nalchik
Z. Kh. Gadieva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zulfiya Kh. Gadieva, 1st year resident in the specialty «Anesthesiology-resuscitation»
Medical Academy
Nalchik
References
1. Alyeva A. A., Nikitin I. G. Lekarstvennoe porazhenie pecheni na fone khimioterapevticheskogo lecheniya u patsientok s rakom molochnoj zhelezy i medikamentoznye podkhody k ego korrektsii. Lechebnoe Delo. 2023; 1: 52–60. (in Russian)
2. Rekomendatsii NCCN (Natsional'noj kompleksnoj onkologicheskoj seti)
3. Rekomendatsii EASL (Evropejskoj assotsiatsii po izucheniyu zabolevanij pecheni)
4. Rukovodstvo AASLD (Amerikanskoj assotsiatsii po izucheniyu zabolevanij pecheni)]
5. Liu Y., Zhong G. C., Tan H. Y., Hao F. B., Hu J. J. Nonalcoholic fatty liver disease and mortality from all causes, cardiovascular disease, and cancer: a meta-analysis. Sci Rep. 2019; 9 (1): 11124. doi: 10.1038/s41598-019-47687-3.
6. Mahrous M. A., El-Azab G. A., Tawfik H. A. Evaluation of clinical outcomes and efficacy of palonosetron and granisetron in combination with dexamethasone in Egyptian patients receiving highly emetogenic chemotherapy. Cancer Chemother Pharmacol. 2021; 88 (1): 121–129. doi: 10.1007/s00280-021-04257-7.
7. Chagay N. B., Mkrtumayn A. M. Estrogen metabolism, lifetime methylation disorders, and breast cancer. Probl Endocrinol. 2019; 65 (3): 161–173. doi: 10.14341/probl10070. (in Russian)
8. Huang Yu.-R., Chiu S.-C., Tseng J.-S., Chen J.-M. M., Wei T.-Y. W., Chen C.-Yu., Kao H.-T. E., Yang C.-Yu. O., Shih Y.-C. E., Yang T.-Y., Chiu K.-Yu., Teng C.-L. J., Yu C.-T. R. The J. M. JD6/HURP axis promotes cell migration via NF-κB-dependent centrosome repositioning and Cdc42-mediated Golgi repositioning. J Cell Physiol. 2022; 237 (12): 4517–4530. doi: 10.1002/jcp.30900.
9.
Review
For citations:
Kambachokova AA, Vologirov AS, Temmoeva LA, Kambachokova ZA, Makhieva ZK, Mamedov RA, Betuganova AK, Zhakova AA, Gadieva ZK. Influence of Liver Pathologies on the Development and Progression of Breast Cancer: Pathophysiological Mechanisms, Therapeutic Strategies and Prevention. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(5-6):52-57. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-5-6-52-57. EDN: QYTJLE
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