Metabolic Therapy in Complex Rehabilitation of Patients After Radiofrequency Ablation

The aim of the study was to evaluate the effectiveness of including the drug cytoflavin in the complex rehabilitation of patients after radiofrequency catheter ablation.

Material and methods. The results of outpatient treatment of 112 patients  after radiofrequency ablation associated with paroxysmal atrial fibrillation were analyzed. The subjects were randomized into two groups: in group 1 (main, N=59), in addition to standard therapy, the drug Cytoflavin (inosine+nicotinamide+riboflavin+succinic acid) was prescribed according to a two-step regimen: 20.0 ml intravenously by drip in 200 ml of 0.9% sodium chloride solution for 10 days, then 2 tablets 2 times a day for 20 days. In the 2nd group (comparison, N=53), in addition to standard therapy, patients received a ten-day course of daily intravenous drip infusions of 10 ml of placebo diluted in 200.0 ml of 0.9% sodium chloride solution, followed by eleutherococcus extract 100 mg, 2 tablets 2 times a day before meals, and combination preparations of B vitamins in the dosage recommended by the manufacturer. The psychoemotional state of patients (using the Hospital Anxiety and Depression Scale (HADS)) and quality of life with a point assessment of subjective characteristics (using the multi-purpose MOS SF-36 questionnaire) were studied dynamically (before and after rehabilitation).

Results. The inclusion of cytoflavin in the regimens contributed to a more significant reduction in the severity of anxiety compared to the patients in the control group — 5.3 times, while in the control group the reduction amounted to only 1.75 times (P˂0.05), and signs of depression — 2 and 1.5 times, respectively (P˂0.05). The effectiveness of the presented outpatient treatment regimen was confirmed by the positive dynamics of patients' quality of life indicators on all SF-36 scales: the initial level of physical health of patients in group 1 increased from 69.8±13.2 to 85.6±4.2 (P˂0.05), and mental health — from 62.3±8.4 to 78.4±3.2 (P˂0.05), while in the comparison group — from 68.7±13.4 to 81.2±3.2 (P˂0.05) and from 61.4±7.3 to 71.3±2.2 (P˂0.05), respectively.

Conclusion. The study showns the effectiveness of using Cytoflavin in the early restorative treatment of patients after radiofrequency catheter ablation, which is manifested by a more pronounced improvement in the psychoemotional state and quality of life of these patients.

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