An Integrative Approach to the Treatment of Breast Cancer in Patients with Thyroid Dysfunction: Molecular Mechanisms, Pathophysiology and Current Therapeutic Strategies
https://doi.org/10.37489/0235-2990-2025-70-9-10-54-61
EDN: WSOEWB
Abstract
Breast cancer (BC) remains the leading cause of cancer-related death among women worldwide. Accumulated evidence reveals a complex relationship between thyroid dysfunction and BC, including an increased risk of development, progression, and worsening prognosis. This article provides a comprehensive review of the molecular mechanisms and pathophysiological aspects underlying this association. The article reviews the existing therapeutic strategies and emphasizes the need for an integrative approach to treating patients with breast cancer and comorbid thyroid conditions. Furthermore, the modern methods for early diagnosis and monitoring of breast cancer are described, taking into account its interactions with other body systems.
About the Authors
Z. Kh. Makhieva
I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Zukhra Kh. Makhieva — 1st-year resident, Department of Oncology and Reconstructive Surgery
Moscow
Z. A. Kambachokova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Zareta A. Kambachokova — D. Sc. in Medicine, Professor at
the Department of Hospital Therapy, Medical Academy
Nalchik
E. A. Vasilyeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Elizaveta A. Vasilyeva — 6th-year student majoring in General Medicine, Medical Academy
Nalchik
L. A. Guchinova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Laura A. Guchinova — 6th-year student in General Medicine, Medical Academy
Nalchik
M. Z. Taov
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Murat Z. Taov — 6th-year student in General Medicine, Medical Academy
Nalchik
S. V. Sageeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Sabina V. Sageeva — university graduate
Nalchik
S. A. Emuzov
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Sultan A. Emuzov — 6th-year student majoring in General
Medicine, Medical Academy
Nalchik
S. M. Ibragimova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Satsita M. Ibragimova — 6th-year student majoring in General Medicine, Medical Academy
Nalchik
R. Kh. Khanzaeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Roza Kh. Khanzaeva — 6th-year student majoring in General
Medicine, Medical Academy
Nalchik
D. T. Abazova
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Diana T. Abazova — 6th-year student majoring in General
Medicine, Medical Academy
Nalchik
Kh. B. Aliyeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Khatimat B. Aliyeva — 6th-year student majoring in General
Medicine, Medical Academy
Nalchik
S. A. Aliyeva
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Salimat A. Aliyeva — 6th-year student majoring in General
Medicine, Medical Academy
Nalchik
E. A. Etuev
Kabardino-Balkarian State University named after H. M. Berbekov
Russian Federation
Russian Federation
Eldar A. Etuev —6th-year student majoring in General Medicine, Medical Academy
Nalchik
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Review
For citations:
Makhieva ZK, Kambachokova ZA, Vasilyeva EA, Guchinova LA, Taov MZ, Sageeva SV, Emuzov SA, Ibragimova SM, Khanzaeva RK, Abazova DT, Aliyeva KB, Aliyeva SA, Etuev EA. An Integrative Approach to the Treatment of Breast Cancer in Patients with Thyroid Dysfunction: Molecular Mechanisms, Pathophysiology and Current Therapeutic Strategies. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(9-10):54-61. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-9-10-54-61. EDN: WSOEWB
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