Changes in Growth Parameters of Clinical Strains of Enterococcus faecalis under the Influence of Nisin
https://doi.org/10.37489/0235-2990-2025-70-11-12-14-17
EDN: RYOSOP
Abstract
Background. Enterococcus faecalis strains have been found to possess active biofilm-forming ability. Therefore, patients with diseases caused by Enterococcus faecalis are prescribed antibiotics in high doses, making the development of drugs with antibiofilm activity urgent. The aim of the study was to evaluate the effect of nisin on the growth parameters of clinical strains of Enterococcus faecalis isolated from the oral cavity. Material and methods. Fifteen clinical strains of E. faecalis in the presence of nisin were studied; the duration of the adaptation phase, growth rate, and area under the curve were evaluated. Results. Nisin shows bactericidal activity against Enterococcus strains, however, the lantibiotic does not have a full antibacterial effect on the biofilm of the studied strains. Therefore, it is urgent to search for additional components with biofilm-destroying ability and to create combined preparations that increase the clinical efficacy of bacteriocins in dentistry.
About the Authors
D. S. Panteleev
E.A. Vagner Perm State Medical University
Russian Federation
Competing Interests:
Russian Federation
Danil S. Panteleev — resident physician of the Department of Orthopedic Dentistry, E.A. Vagner Perm State Medical University.
Perm
Competing Interests:
None
A. P. Godovalov
E.A. Vagner Perm State Medical University
Russian Federation
Competing Interests:
Russian Federation
Anatoliy P. Godovalov — Ph. D. in Medicine, Associate Professor, E. A. Vagner Perm State Medical University.
Perm
Scopus Author ID 57204065570
Competing Interests:
None
M. V. Yakovlev
E.A. Vagner Perm State Medical University
Russian Federation
Competing Interests:
Russian Federation
Mikhail V. Yakovlev — Ph. D. in Medicine, E. A. Vagner Perm State Medical University.
Perm
Competing Interests:
None
References
1. Rams T. E., Feik D., Young V., Hammond B. F., Slots J. Enterococci in human periodontitis. Oral Microbiol Immunol. 1992; 7 (4): 249–252. doi: doi: 10.1111/j.1399-302x.1992.tb00034.x.
2. Coleri A., Cokmus C., Ozcan B., Akcelik M., Tukel C. Determination of antibiotic resistance and resistance plasmids of clinical Enterococcus species. J Gen Appl Microbiol. 2004; 50 (4): 213–219. doi: 10.2323/jgam.50.213.
3. Barbosa-Ribeiro M., Gomes B. P. F. A., Arruda-Vasconcelos R., Monteiro I. A., Costa M. J.F., Sette-de-Souza P. H. Antibiotic resistance profile of clinical strains of enterococci from secondary/persistent endodontic infections: what do we know? A systematic review of clinical studies. J Endod. 2024; 50 (3): 299–309. doi: 10.1016/j.joen.2023.12.007.
4. Megran D. W. Enterococcal endocarditis. Clin Infect Dis. 1992; 15 (1): 63–71. doi: 10.1093/clinids/15.1.63.
5. Osipovich O. A., Godovalov A. P. K voprosu o roli vospalitel'nykh zabolevanii v razvitii besplodiya u zhenshchin. Meditsinskii Al'manakh. 2016; 5 (45): 85–87. (in Russian)
6. Rams T. E., Feik D., Mortensen J. E., Degener J. E., van Winkelhoff A. J. Antibiotic susceptibility of periodontal Enterococcus faecalis. J Periodontol. 2013; 84 (7): 1026–33. doi: 10.1902/jop.2012.120050.
7. Matchanova F. S. Aktual'nost' problemy rezistentnosti k protivomikrobnym preparatam v mire. Vestnik KazNMU. 2018; 2: 365–367. (in Russian)
8. Ermolenko E. I. Bakteriotsiny enterokokkov: problemy i perspektivy ispol'zovaniya (obzor literatury). Vestnik Sankt-Peterburgskogo universiteta. Meditsina. 2009; 3: 78–93. (in Russian)
9. Tyumenceva V. S., Abdullaeva A. M., Blinkova L. P. Study of antimicrobial properties of nizin. Vestnik of the Mari State University. Series «Agricultural Sciences. Economic Sciences». 2023; 9 (1): 56–62. (in Russian)
10. Khusainov R., van Heel A. J., Lubelski J., Moll G. N., Kuipers O. P. Identification of essential amino acid residues in the nisin dehydratase NisB. Front Microbiol. 2015; 26: 6: 102. doi: 10.3389/fmicb.2015.00102.
11. Egan K., Field D., Rea M. C., Ross R. P., Hill C., Cotter P. D. Bacteriocins: novel solutions to age old spore-related problems? Front Microbiol. 2016; 8: 7: 461. doi: 10.3389/fmicb.2016.00461.
Review
For citations:
Panteleev DS, Godovalov AP, Yakovlev MV. Changes in Growth Parameters of Clinical Strains of Enterococcus faecalis under the Influence of Nisin. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(11-12):14-17. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-11-12-14-17. EDN: RYOSOP
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