Diazabicyclooctane-Based Inhibitor-Protected β-Lactams: Mechanisms of Resistance in Gram-Negative Bacteria

The introduction of diazabicyclooctane-based inhibitor-protected β-lactams into clinical practice has significantly expanded the treatment options against infections caused by carbapenemase-producing Gram-negative bacteria. Nevertheless, the actual clinical progress has been limited due to the rapid development and spread of resistance to the new drugs. This review summarizes and analyzes current data on the mechanisms of resistance to inhibitor-protected β-lactams.

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