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Algae and Type 2 Diabetes: New Treatment Strategies

https://doi.org/10.1016/0235-2990-2019-64-11-12-54-67

Abstract

The review contains recent materials on the effects of extracts, polysaccharides, and polyphenols from brown algae in type 2 diabetes mellitus, which are a potential basis for creating effective antihyperglycemic agents. These biologically active substances are polyvalent biomodulators that have a multi-component effect in diabetes. These biopolymers reduce blood glucose levels, increase insulin production, decrease insulin resistance, inhibit α-amylase and α-glucosidase production, have antioxidant and anti-inflammatory activity, protect pancreatic, liver, and kidney tissues from high glucose concentrations. Algae are promising candidates for creating new generation drugs with associated activity, functional foods and dietary supplements for use in type 2 diabetes mellitus.

About the Authors

N. N. Besednova
Somov Research Institute of Epidemiology and Microbiology
Russian Federation


S. P. Ermakova
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences
Russian Federation


T. A. Kuznetsova
Somov Research Institute of Epidemiology and Microbiology
Russian Federation


I. D. Makarenkova
Somov Research Institute of Epidemiology and Microbiology
Russian Federation


S. P. Krizhanovsky
Medical Association of the Far Eastern Branch of the Russian Academy of Sciences
Russian Federation


B. G. Andryukov
Somov Research Institute of Epidemiology and Microbiology
Russian Federation


T. S. Saporozhets
Somov Research Institute of Epidemiology and Microbiology
Russian Federation


Review

For citations:


Besednova N.N., Ermakova S.P., Kuznetsova T.A., Makarenkova I.D., Krizhanovsky S.P., Andryukov B.G., Saporozhets T.S. Algae and Type 2 Diabetes: New Treatment Strategies. Antibiot Khimioter = Antibiotics and Chemotherapy. 2019;64(11-12):54-67. (In Russ.) https://doi.org/10.1016/0235-2990-2019-64-11-12-54-67

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ISSN 0235-2990 (Print)