In vitro Efficacy of Ingavirin Against the Mexican Pandemic Subtype H1N1 of Influenza A Virus, Strains A/California/04/2009 and A/California/07/2009
Abstract
Ingavirin® was shown to be efficient in inhibition of the influenza virus strains A/California/04/2009 and A/California/07/2009 (H1N1) in the MDCK cell culture. The coefficient of the cytopathic activity inhibition amounted to 50 and 60%, and the inhibition coefficients of the specific hemagglutinin formation were 50 and 50%, and 79,1 and 75% before and after the enrichment in chick embryos respectively.
About the Authors
S. YA. Loginova
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
S. V. Borisevich
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
M. V. Lykov
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
E. V. Vedenina
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
G. V. Borisevich
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
V. P. Bondarev
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
V. E. Nebolsin
Valenta Farmacevtica, Moscow
Russian Federation
Russian Federation
A. G. Chuchalin
Research Institute of Pulmonology, Federal Medico-Biological Agency of the Russian Federation, Moscow
Russian Federation
Russian Federation
References
1. Schnurrenberger P.R., Woods G.T., Martin R.J. Serologic evidence of human infection with swine influenza virus. Am Rev Respir Dis 1970; 102: 3: 356-361.
2. Webster R.G., Bean W.J., Gorman O.T. et al. Evolution and ecology of influenza A viruses. Microbiol Rev 1992; 56: 1: 152-179.
3. Myers K.P., Olsen C.W., Gray G.C. Cases of swine influenza in humans: a review of the literature. Clin Infect Dis 2007; 44: 8: 1084-1088.
4. Wells D.L., Hopfensperger D.J., Arden N.H. et al. Swine influenza virus infections. Transmission from ill pigs to humans at a Wisconsin agricultural fair and subsequent probable person-to-person transmission. JAMA 1991; 265: 4: 478-481.
5. Vincent A.L., Ma W., Lager K.M. et al. Swine influenza viruses: a North American perspective. Adv Virus Res 2008; 72: 127-154.
6. Vincent A.L., Swenson S.L., Lager K.M. et al. Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States. Vet Microbiol 2009; 137: 1-2: 51-59.
7. Newman A.P., Reisdorf E., Beinemann J. et al. Human case of swine influenza A (H1N1) triple reassortant virus infection, Wisconsin. Emerg Infect Dis 2008; 14: 9: 1470-1472.
8. Swine Influenza A (H1N1) Infection in Two Children - Southern California, March-April 2009. http://www.cdc.gov/mmwr/preview/mmwrhtml/ mm58d0421a1.htm
9. http://www.who.int/csr/resources/publications/swineflu/WH0_0FFLU2009 _05_15.pdf.
10. http://www.who.int/csr/don/2009_06_26/en/index.html.
11. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ. / Под ред Р.У. Хабриева, М.: 2005.
Review
For citations:
Loginova S.Ya., Borisevich S.V., Lykov M.V., Vedenina E.V., Borisevich G.V., Bondarev V.P., Nebolsin V.E., Chuchalin A.G. In vitro Efficacy of Ingavirin Against the Mexican Pandemic Subtype H1N1 of Influenza A Virus, Strains A/California/04/2009 and A/California/07/2009. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(3-4):15-17. (In Russ.)
Views:
390
Email this article 