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Антибиотики и Химиотерапия

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Ядерные рецепторы и метаболизм ксенобиотиков

Об авторах

С. Н. Ларина
Московская медицинская академия им. И.М. Сеченова; Институт клинической фармакологии ФГУ НЦЭСМП, Москва
Россия


И. В. Игнатьев
Московская медицинская академия им. И.М. Сеченова; Институт клинической фармакологии ФГУ НЦЭСМП, Москва
Россия


Н. В. Чебышев
Московская медицинская академия им. И.М. Сеченова; Институт клинической фармакологии ФГУ НЦЭСМП, Москва
Россия


В. Г. Кукес
Московская медицинская академия им. И.М. Сеченова; Институт клинической фармакологии ФГУ НЦЭСМП, Москва
Россия


Список литературы

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3. Conney A.H. Cancer Res 1982; 42: 4875-4917.

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6. Hardwick J.P., Gonzalez F.J., Kasper C.B. Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16α-carbonitrile. Characterization of its mRNA, gene, and induction response. J Biol Chem 1983; 258: 10182-10186.

7. Watkins P.B., Wrighton S.A., Maurel P., Schuetz E.G. et al. Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci USA. 1985 82: 6310-3614.

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9. Mangelsdorf D.J., Thummel C., Beato M. et al. The nuclear receptor superfamily: the second decade. Ibid; 1995; 83: 835-839.

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13. Jones S.A., Moore L.B., Shenk J.L. et al. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverger during evolution. Mol Endocrinol 2000; 14: 27-39.

14. Elshourbagy N.A., Guzelian P.S. Separation, purification, and characterization of novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16α-carbonitrile. J Biol Chem 1980; 255: 1279-1285.

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16. Kliewer et al. Endocrine Rewies, October 2002; 23: 5: 687-702.

17. Masuyama H., Hiramatsu Y., Mizutani Y. et al. The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse. Mol Cell Endocrinol 2001; 172: 47-56.

18. Synold T.W., Dussault I., Forman B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001; 7: 584-590.

19. Wan Y.U.Y., An D., Cai Y., Repa J. et al. Hepatocyte-specific mutation establishes retinoid X receptor as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 2000; 20: 4436-4444.

20. Barwick J.L., Quattrochi L.C., Mills A.S. et al. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 1996; 50: 10-16.

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23. Geick A., Eichelbaum M., Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. Ibid; 2001; 276: 14581-14587.

24. Kast H.R., Goodwin B., Tarr P.T. et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Boil Chem 2002; 277: 2908-2915.

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26. Moore L.B., Parks D.J., Jones S.A., Bledsoe R.K. et al. Orphan nuclear receptors constitutive androstane receptor and pregnan X receptor share xenobiotic and steroid ligands. J Biol Chem 2000; 275: 15122-15127.

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28. Kawamoto T., Sueyoshi T., Zelko I. et al. Phenobarbutal-responsive nuclear translocation of the receptor CAR in induction of the CYR2B gene. Mol Cell Biol 1999; 19: 6318-6322.


Рецензия

Для цитирования:


Ларина С.Н., Игнатьев И.В., Чебышев Н.В., Кукес В.Г. Ядерные рецепторы и метаболизм ксенобиотиков. Антибиотики и Химиотерапия. 2009;54(3-4):42-48.

For citation:


Larina S.N., Ignatiev I.V., Chebyshev N.V., Kukes V.G. Nuclear Receptors and Metabolism of Xenobiotics. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(3-4):42-48. (In Russ.)

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