Viferon Suppositoria in Therapy of Relapsing Herpesvirus Infection in Women
Abstract
The therapeutic efficacy of Viferon, a recombinant human interferon alpha-2b (rectal suppositoria) was studied in the therapy of relapsing herpesvirus infection in women. The clinical efficacy of the drug was recorded in 90% of the patients. The analysis of the remote results of the treatment made it possible to conclude that the Viferon suppositoria had an antirelapsing activity.
About the Authors
A. N. Vasilyev
Institute of Preclinical and Clinical Investigation of Drugs; Scientific Centre of Investigation of Medicinal Products, Moscow; I. M. Sechenov Moscow Medical Academy; N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Moscow
Russian Federation
Russian Federation
ZN. A. Kagramanova
Institute of Preclinical and Clinical Investigation of Drugs; Scientific Centre of Investigation of Medicinal Products, Moscow; I. M. Sechenov Moscow Medical Academy; N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Moscow
Russian Federation
Russian Federation
V. V. Malinovskaya
Institute of Preclinical and Clinical Investigation of Drugs; Scientific Centre of Investigation of Medicinal Products, Moscow; I. M. Sechenov Moscow Medical Academy; N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Moscow
Russian Federation
Russian Federation
V. V. Parfenov
Institute of Preclinical and Clinical Investigation of Drugs; Scientific Centre of Investigation of Medicinal Products, Moscow; I. M. Sechenov Moscow Medical Academy; N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Moscow
Russian Federation
Russian Federation
References
1. Кетлинский С. А., Симбирцев А. С., Воробьев А. А. Эндогенные иммуномодуляторы, 1992.
2. Малиновская В. В., Сускова В. С., Абаева 3. Р. и др. Особенности иммунного гомеостаза и интерферонового статуса новорожденных от матерей, инфицированных цитомегаловирусом и вирусом простого герпеса. Russian J Immunol 2000; 5: 2: 177-184
3. Кузнецов В. П., Маркелова Е. В., Колесникова Н. В. и др. Цитокины в патогенезе инфекций и иммунокоррекция. Аллергол иммунол 2001; 2: 2: 6: 3
4. Черешнев В. А, Юшков Б. Г., Климин В. Г., Лебедева Е. В. Иммунофизиология, Екатеринбург: 2002.
5. Хаитов В. А., Гусев Е. Ю. Иммунология локального и системного воспаления. Аллергол иммунол 2001; 2: 2: 5: 6-7.
6. Фрейдлин И. С., Назаров П. Г. Регуляторные функции провоспалительных цитокинов и острофазных белков. Вест РАМН 1999; 5: 28-32.
7. Igarashi T., Konno R., Okamoto S. еі al. Involvement of granule mediated apoptosis in the cyclic changes of normal human endometrium. Tohoku J Exp Med 2001; 193: 1: 13-25.
Review
For citations:
Vasilyev A.N., Kagramanova Z.A., Malinovskaya V.V., Parfenov V.V. Viferon Suppositoria in Therapy of Relapsing Herpesvirus Infection in Women. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(5-6):54-58. (In Russ.)
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