In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen
Abstract
The experimental investigation of the Ingavirin® antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up to 0.001 CPD50/cell), the inhibition of the virus cytopathic effect by Ingavirin® amounted to 100% in all the tested concentrations (including the low ones) added either before or after the culture contamination. Ingavirin® was efficient in inhibition of the adenovirus type 5 reproduction in the HeLa cell culture.
About the Authors
S. YA. Loginova
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
S. V. Borisevich
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
V. A. Maksimov
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
V. P. Bondarev
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Russian Federation
Russian Federation
V. E. Nebolsin
Valenta Farmacevtica, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Loginova S.Ya., Borisevich S.V., Maksimov V.A., Bondarev V.P., Nebolsin V.E. In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(7-8):16-18. (In Russ.)
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