Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya
Abstract
A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins ofunusual component structure: the content of cyclosporin A (55—60%) was the same as that in the substances produced by the majority of the described cultures, the content of cyclosporin B was much higher (about 40%) and the content of cyclosporin C was relatively low (about 3%). An appreciable content of cyclosporin (Leu4)Cs (3%) proved to be of interest.
About the Authors
M. V. Bibikova
National Research Centre of Antibiotics, Moscow M. Emanuel Institute of Biochemical Physics, Moscow
Russian Federation
Russian Federation
T. A. Darkhanova
National Research Centre of Antibiotics, Moscow M. Emanuel Institute of Biochemical Physics, Moscow
Russian Federation
Russian Federation
I. A. Spiridonova
National Research Centre of Antibiotics, Moscow M. Emanuel Institute of Biochemical Physics, Moscow
Russian Federation
Russian Federation
A. N. Danilenko
I. M. Sechenov Moscow Medical Academy
Russian Federation
Russian Federation
A. V. Katlinsky
I. M. Sechenov Moscow Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Bibikova M.V., Darkhanova T.A., Spiridonova I.A., Danilenko A.N., Katlinsky A.V. Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(9-10):6-9. (In Russ.)
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