Ribavirin Prophylaxis and Therapy of Experimental West Nile Fever
Abstract
Investigation of the efficacy of ribavirin against the West Nile virus in standard cell cultures showed that in high concentrations it inhibited the virus reproduction (the inhibition coefficient of 100%). In the experiments on albino mice infected with the West Nile virus in a dose of 10 LD50 ribavirin was used in the form of injections in a dose of 20 mg/kg for 7 days in the scheme of urgent prophylaxis and proved to be highly efficient in protection of the animals from death (85-percent survival).
About the Authors
S. YA. Loginova
Virological Centre, Branch of Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
S. V. Borisevich
Virological Centre, Branch of Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
YU. I. Pashchenko
Virological Centre, Branch of Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
V. P. Bondarev
Virological Centre, Branch of Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
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Review
For citations:
Loginova S.Ya., Borisevich S.V., Pashchenko Yu.I., Bondarev V.P. Ribavirin Prophylaxis and Therapy of Experimental West Nile Fever. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(11-12):17-20. (In Russ.)
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