Experience with Antibiotics in the Treatment of Ulceronecrotic Tonsillitis Due to Vaccination by Tabletted Pox Vaccine
Abstract
Clinical trials of tabletted pox vaccine revealed development of tonsillitis as a postvaccinal reaction in some volunteers: ulceronecrotic lesions in the tonsils, lymphadenitis, hyperthermia and asthenia. The main cause of the local inflammatory reactions was activation of the host opportunistic microflora including hemolytic streptococci and Staphylococcus aureus. For the treatment of the infectious complications systemic antimicrobials, such as benzylpenicillin, amoxicillin, ampicillin, cefazolin and fluoroquinolones (ciprofloxacin) in combination with the symptomatic therapy were used. The treatment course of 9 days provided complete elimination of the postvaccinal reactions, the specific antibody generation being not affected.
About the Authors
V. P. Bondarev
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
I. V. Borisevich
Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Kirov
Russian Federation
Russian Federation
S. A. Melnikov
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
A. V. Kaskov
Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Kirov
Russian Federation
Russian Federation
E. E. Shagarov
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
N. K. Chernikova
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
T. V. Dorokhina
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
A. V. Rylov
Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Kirov
Russian Federation
Russian Federation
T. A. Bondareva
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
A. I. Terentyev
Virological Centre, Branch of the Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Sergiev Posad
Russian Federation
Russian Federation
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Review
For citations:
Bondarev V.P., Borisevich I.V., Melnikov S.A., Kaskov A.V., Shagarov E.E., Chernikova N.K., Dorokhina T.V., Rylov A.V., Bondareva T.A., Terentyev A.I. Experience with Antibiotics in the Treatment of Ulceronecrotic Tonsillitis Due to Vaccination by Tabletted Pox Vaccine. Antibiot Khimioter = Antibiotics and Chemotherapy. 2010;55(3-4):21-23. (In Russ.)
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