Activation of Innate Immunity Human Cells by Lipopolisaccharide and Extracellular Polysaccharid Produced by Marine Bacteria
Abstract
It has been shown that using the cytometric method lipopolysaccharide (LPS) and extracellular polysaccharide (EPS) isolated from marine bacteria Pseudoalteromonas nigrifaciens increase the relative amount of monocytes synthesizing IL-12. LPS and EPS enhance the cytotoxic potential of NK cells, enhancing their degranulation (expression of membrane CD107a), intracellular synthesis of IFN-y and increasing the expression of CD25, CD69, HLA-DR, CD11b, and CD54 molecules.
About the Authors
T. P. Smolina
Somov Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
T. S. Zaporozhets
Somov Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
N. N. Besednova
Somov Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
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Review
For citations:
Smolina T.P., Zaporozhets T.S., Besednova N.N. Activation of Innate Immunity Human Cells by Lipopolisaccharide and Extracellular Polysaccharid Produced by Marine Bacteria. Antibiot Khimioter = Antibiotics and Chemotherapy. 2017;62(7-8):3-7. (In Russ.)
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