Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study)
Abstract
The best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of а-interferon in combination with cycloferon provided remission in 44.1% of the lamivudine-resistant patients. The use of cycloferon in the therapy of chronic hepatitis B made it possible to lower the frequency and manifestation level of the side effects and prevented the lamivudine resistance development and generation of the virus mutants.
About the Authors
T. V. Sologub
I. I. Mechnikov St.Petersburg State Medical Academy
Russian Federation
Russian Federation
A. A. Shuldyakov
Saratov State Medical University
Russian Federation
Russian Federation
L. G. Goryacheva
Research Institute of Children Infections, St.Petersburg
Russian Federation
Russian Federation
I. P. Baranova
Penza State Institute of Postgraduate Medical Training
Russian Federation
Russian Federation
YU. N. Linkova
Research and Technological Pharmaceutical Co. POLYSAN, St.Petersburg
Russian Federation
Russian Federation
A. L. Kovalenko
Research and Technological Pharmaceutical Co. POLYSAN, St.Petersburg
Russian Federation
Russian Federation
M. G. Romantsov
I. I. Mechnikov St.Petersburg State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Sologub T.V., Shuldyakov A.A., Goryacheva L.G., Baranova I.P., Linkova Yu.N., Kovalenko A.L., Romantsov M.G. Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study). Antibiot Khimioter = Antibiotics and Chemotherapy. 2010;55(9-10):37-41. (In Russ.)
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