Investigation of Antiviral Activity of Adamantan Boron Derivaties on Pandemic Influenza Virus Models
Abstract
Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes - boron-containing compounds is discussed.
About the Authors
S. G. Markushin
I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow; N.D. Zelinsky Research Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
N. A. Kantarov
I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow; N.D. Zelinsky Research Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
S. V. Artyushenko
I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow; N.D. Zelinsky Research Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
I. I. Akopova
I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow; N.D. Zelinsky Research Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
I. B. Koptyaeva
I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow; N.D. Zelinsky Research Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
YU. N. Bubnov
I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow; N.D. Zelinsky Research Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Markushin S.G., Kantarov N.A., Artyushenko S.V., Akopova I.I., Koptyaeva I.B., Bubnov Yu.N. Investigation of Antiviral Activity of Adamantan Boron Derivaties on Pandemic Influenza Virus Models. Antibiot Khimioter = Antibiotics and Chemotherapy. 2011;56(5-6):3-6. (In Russ.)
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