Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics
Abstract
Clinical and immunological parameters in the children with perinatal HIV infection were investigated in the dynamics of the longterm prospective observation. It was revealed, that all the HIV infected children had clinical signs of immunodeficiency and laboratory signs of combined damage of the immune system. The complex of therapeutic measures, including antiretroviral therapy, prevention of opportunistic and acute respiratory infections, rational immunotherapy to stimulate production of endogenous interferon and normalization of the balance of cytokines significantly reduced the frequency of the clinical manifestations of the infectious syndrome and improved the patients resistance to infections.
About the Authors
A. G. Petrova
Irkutsk State Medical University
Russian Federation
Russian Federation
E. V. Moskaleva
Irkutsk State Medical University
Russian Federation
Russian Federation
S. V. Smirnova
Research Institute for Medical Problems of the North, Siberian Branch of the Russian Academy of Medical Sciences, Krasnoyarsk
Russian Federation
Russian Federation
M. G. Evseeva
Irkutsk State Medical University
Russian Federation
Russian Federation
S. N. Shugaeva
Irkutsk State Medical University
Russian Federation
Russian Federation
M. G. Romantsov
Scientific and Technological Pharmaceutical Co. POLYSAN, St.Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Petrova A.G., Moskaleva E.V., Smirnova S.V., Evseeva M.G., Shugaeva S.N., Romantsov M.G. Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics. Antibiot Khimioter = Antibiotics and Chemotherapy. 2011;56(5-6):54-63. (In Russ.)
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