Comparative Study of Antiviral Activity of Luteolin and 7,3’-Disulfate Luteolin
Abstract
Antiviral activity of 7,3’-disulfate luteolin, extracted from Zostera marina was studied on an experimental model of tick-borne encephalitis (TBE) in vivo and in vitro. The drug increased the survival of the experimental mice infected with TBE virus and prolonged their lifespan. It was shown that 7,3’-disulfate luteolin reduced the virus accumulation in the SPEV cells by 2.0-4.0 lg TCID50/ml.
About the Authors
N. V. Krylova
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
A. M. Popov
Тихоокеанский институт биоорганической химии ДВО РАН
Russian Federation
Russian Federation
G. N. Leonova
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
A. А. Artyukov
Тихоокеанский институт биоорганической химии ДВО РАН
Russian Federation
Russian Federation
O. S. Maistrovskaya
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Krylova N.V., Popov A.M., Leonova G.N., Artyukov A.А., Maistrovskaya O.S. Comparative Study of Antiviral Activity of Luteolin and 7,3’-Disulfate Luteolin. Antibiot Khimioter = Antibiotics and Chemotherapy. 2011;56(11-12):7-10. (In Russ.)
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