The Etiological Structure and Antibiotic Resistance of Pathogens of Community-Acquired Infections of the Urinary Tract in St. Petersburg, 2013-2015
Abstract
A retrospective analysis of the results of diagnosis of urinary tract infections and antibiotic susceptibility of pathogens isolated from patients from outpatient clinics in 2013-2015 was conducted. 1118 isolates (76.6%) were obtained from women aged 18 to 91 years (mean age 46.3+22.2 years) and 341 (23.4%) from men aged 19 to 85 years (mean age 52.1+19.7 years). Among 1459 uropathogens, representatives of the Enterobacteriaceae family (77.0%) prevailed, while, gram-positive bacteria (18.3%) and non-fermenting gram-negative bacteria (4.2%) were less common. The lowest level of resistance was exhibited by isolates of E.coli: 45.7% of isolates were resistant to ampicillin, 39.7% - to inhibitor-protected penicillins, up to 21.7% - to fluoroquinolones, 17.5-18.7% - to cephalosporins, up to 10,7% - to aminoglycosides. Along with carbapenems, high activity against Escherichia coli was retained by nitrofurantoin, to which only 7.0% of isolates were insensitive. The greatest level of resistance was detected among enterobacteria of Citrobacter freundii, Morganella spp., Serratia spp., Cedecea spp., Providencia spp. Resistance to oxacillin showed more than 40% of both Staphylococcus aureus and coagulase-negative staphylococci. The spread of resistance to cephalosporins of III-IV generations among Enterobacteriaceae should be considered as the most unfavorable trend, which is probably associated with production of extended-spectrum beta-lactamases.
About the Authors
O. A. Kameneva
City Children's Hospital No. 22
Russian Federation
Russian Federation
S'. E. Morozova
City Children's Hospital No. 22
Russian Federation
Russian Federation
O. E. Punchenko
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
K. G. Kosyakova
City Children's Hospital No. 22; North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
S. V. Sidorenko
North-Western State Medical University named after I. I. Mechnikov; Research Institute of Children's Infections
Russian Federation
Russian Federation
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For citations:
Kameneva O.A., Morozova S.E., Punchenko O.E., Kosyakova K.G., Sidorenko S.V. The Etiological Structure and Antibiotic Resistance of Pathogens of Community-Acquired Infections of the Urinary Tract in St. Petersburg, 2013-2015. Antibiot Khimioter = Antibiotics and Chemotherapy. 2017;62(9-10):19-26. (In Russ.)
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