Invasive Mucormycosis in Patients with Hemoblastosis in St.-Petersburg
Abstract
Thirty four patients with mucormycosis in 10 hospitals of St. Petersburg were observed in 2004-2013. The most frequent underlying diseases of mucormycosis were acute leukoses (64%). In 100% of the patients mucormycosis developed as a nosocomial infection. The risk factors, etiology, basic clinical signs and strategy in the treatment of mucormycosis were analyzed.
About the Authors
S. N. Khostelidi
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
A. G. Volkova
I.P. Pavlov St. Petersburg State Medical University
Russian Federation
Russian Federation
M. O. Popova
I.P. Pavlov St. Petersburg State Medical University
Russian Federation
Russian Federation
T. S. Bogomolova
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
A. S. Kolbin
Pediatric Hospital No. 1
Russian Federation
Russian Federation
E. G. Boychenko
Pediatric Hospital No. 1
Russian Federation
Russian Federation
N. V. Medvedeva
Municipal Hospital No. 31
Russian Federation
Russian Federation
E. I. Podoltseva
Municipal Hospital No. 31
Russian Federation
Russian Federation
A. V. Klimovich
Municipal Hospital No. 31
Russian Federation
Russian Federation
M. B. Belogurova
Municipal Hospital No. 31
Russian Federation
Russian Federation
I. S. Zuzgin
Leningrad Regional Clinical Hospital
Russian Federation
Russian Federation
L. S. Zuborovskaya
I.P. Pavlov St. Petersburg State Medical University
Russian Federation
Russian Federation
N. V. Vasilyeva
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
N. N. Klimko
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
References
1. Климко H.Н. Микозы: диагностика и лечение. Руководство для врачей 2-е издание.М.: 2008; 335.
2. Хостелиди С.Н. Главное о зигомикозе (обзор). Проблем мед. микол. 2006; 8: 4: 8-18.
3. Roden M.M., Zaoutis T.E., Buchanan W.L. et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005; 41: 634-653.
4. De Pauw B., Walsh T.J., Donnelly J.P. et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases. Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008; 46: 12: 1813-1821.
5. Segal В.H., Herbrecht R., Stevens D.A. at al. Defining Responses to Therapy and Study Outcomes in Clinical Trials of Invasive Fungal Diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer Consensus Criteria. CID 2008; 47: 674-683.
6. Skiada A., Pagano L., Groll A. et al. European Confederation of Medical Mycology Working Group on Zygomycosis. Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007. Clin Microbiol Infect 2011; 17: 12: 1859-1867.
7. Pagano L., Valentini C.G., Posteraro B. et al. Zygomycosis in Italy: a survey of FIMUA-ECMM (Federazione Italiana di Micopatologia Umana ed Animale and European Confederation of Medical Mycology). Chemotherapy 2009; 3: 322-329.
8. Petrikkos G., Skiada A., Lortholary O., Roilides E., Walsh T.J., Kontoyiannis D. Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis 2012; 54: 1: 23-34.
9. Pagano L., Fianchi L., Leone G. Fungal pneumonia due to molds in patients with hematological malignancies. Chemotherapy 2006; 18: 4: 339-352.
10. Pagano L., Offidani M., Fianchi L. et al. Mucormycosis in hematologic patients. Haematologica 2004; 89: 2: 207-214.
11. Lanternier F., Dannaoui E., Morizot G., Elie C., Garcia-Hermoso D., Huerre M., Bitar D., Dromer F., Lortholary O., French Mycosis Study Group. A global analysis of mucormycosis in France: the RetroZygo Study (2005-2007). Clin Infect Dis 2012; 54: 1: 35-43.
12. Gleissner B., Schilling A., Anagnostopolous I., Siehl I., Thiel E. Improved outcome of zygomycosis in patients with hematological diseases? Leuk Lymphoma 2004; 45: 7 1351-1360.
13. Javier Pastor F., Guarro J. Micafungin: experimental therapy of fungal infections in animal models. Rev Iberoam Micol 2009; 26: 1: 42-48.
14. Ogawa T., Takezawa K., Tojima I., Shibayama M., Kouzaki H., Ishida M., Okabe H., Shimizu T. Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin. Auris Nasus Larynx 2012; 39: 2: 224-228.
15. Van Sickels N., Hoffman J., Stuke L., Kempe K. Survival of a patient with trauma-induced mucormycosis using an aggressive surgical and medical approach. J Trauma 2011; 70: 2: 507-509.
16. Khostelidi S.N., Klimko N.N., Bogomolova T.S. et al. Mucormycosis in Saint Petersburg, Russia. Mycosеs: Diagn, Ther Prophyl of Fungal Dis 2011; 54: 2: 99.
17. Khostelidi S.N., Klimko N.N., Bogomolova T.S. et al. Mucormycosis in patients with haematological and oncologycal diseases in Saint-Petersburg, Russia. 22nd European Congress of Clinical Microbiology and Infectious Diseases. Book of abstracts. London, United Kingdom. 2012; 162.
Review
For citations:
Khostelidi S.N., Volkova A.G., Popova M.O., Bogomolova T.S., Kolbin A.S., Boychenko E.G., Medvedeva N.V., Podoltseva E.I., Klimovich A.V., Belogurova M.B., Zuzgin I.S., Zuborovskaya L.S., Vasilyeva N.V., Klimko N.N. Invasive Mucormycosis in Patients with Hemoblastosis in St.-Petersburg. Antibiot Khimioter = Antibiotics and Chemotherapy. 2013;58(7-8):23-29. (In Russ.)
Views:
365
Email this article 