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Determination of Oligomycins Hydrophobicity Parameters

Abstract

The parameters of hydrophobicity of five oligomycins, i. e. A, B, C, F and SC-II were determined by HPLC. The location of the ascending hydrophobicity parameter was set: oligomycin B < oligomycin SC-II < oligomycin A < oligomycin F < oligomycin C.

About the Authors

A. N. Danilenko
N.M. Emmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow
Russian Federation


M. V. Bibikova
VIORIN, Moscow
Russian Federation


I. A. Spiridonova
VIORIN, Moscow
Russian Federation


References

1. Бибикова М.В., Грамматикова Н.Э. и др. Механизм биологической активности макролидных антибиотиков-ингибиторов F0F1-АТФазы. Антибиотики и химиотер 2003; 12: 25-32.

2. Laatsch H., Kellner M., Gerhard Wolfa G. et al. Oligomycin F, a new immunosuppressive homolog of oligomycin A. J Antibiot 1993; 46; 9; 1334-1341.

3. Salomon A.R., Voehringer D.W., Herzenberg L.A., Khosla C. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F0F1ATPase PNAS 2000; 97: 26: 14766- 14771.

4. Лысенкова Л.H., Королев A.M., Штиль A.A. И др. Цитотоксические полусинтетические производные макролидного антибиотика олигомицина А и способ их получения. Патент на изобретение № 2454420, РФ, 2012.

5. Wender P.A., Janhowski O.D., Tabet E.A., Sato H. Toward a structure-activity relationship for appoptolidin: selective functionalization of the hydroxyl group array. Org Lett 2003; 5: 4: 487-490.

6. Fujita T., Iwasa J., Hansch C. A new substituent constant, pi, derived from partition coefficients. J Am Chem Soc 1964; 86: 5175-5180.

7. Valko K., Siegel P. New chromatographic hydrophobicity index(φ0) based on the slope and the intercept of the log K' versus organic phase concentration plot. J Chromatography 1993; 631: 49-61.

8. Кабанов A.E., Даниленко A.H., Спиридонова И.A. и др. Определение структуры основного копонента антибиотического комплекса, образуемого Streptomyces griseolus 182. Антибиотики и химиотер. 2003; 48: 10: 16-20.

9. Бибикова М.В., Грамматикова Н.Э., Спиридонова И.A. и др. Штамм Streptomyces sp. 17 - продуцент олигомицина SC-II (характеристика продуцента, биологические свойства антибиотика). Антибиотики и химиотер. 2012; 57: 7-8: 3-6.


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For citations:


Danilenko A.N., Bibikova M.V., Spiridonova I.A. Determination of Oligomycins Hydrophobicity Parameters. Antibiot Khimioter = Antibiotics and Chemotherapy. 2014;59(3-4):3-6. (In Russ.)

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ISSN 0235-2990 (Print)