Induction of Type 1, 2 and 3 Interferons by Acridone Acetates
Abstract
The induction profile of endogenous interferons of three types under the action of meglumine acridone acetate and sodium acridone acetate, as well as the characteristics of the kinetics of their accumulation and circulation in the blood of experimental animals are described. Meglumine acridone acetate provided balance in induction, production and circulation of the interferons in the blood vs. sodium acridone acetate under the same conditions. The optimal dose of meglumine acridone acetate (2.0-3.5 mg/mouse) with effective, consecutive and overlapping induction-production of the interferons ensured their prolonged (for 72 hours) circulation in the blood after a single administration.
About the Authors
S. S. Grigoryan
N. F. Gamaleya Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
A. Yu. Petrov
POLYSAN Co
Russian Federation
Russian Federation
E. I. Isaeva
N. F. Gamaleya Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
M. A. Muzykin
POLYSAN Co
Russian Federation
Russian Federation
A. L. Kovalenko
Institute of Toxicology of Federal Medico-Biological Agency
Russian Federation
Russian Federation
M. G. Romantsov
I. I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Grigoryan S.S., Petrov A.Yu., Isaeva E.I., Muzykin M.A., Kovalenko A.L., Romantsov M.G. Induction of Type 1, 2 and 3 Interferons by Acridone Acetates. Antibiot Khimioter = Antibiotics and Chemotherapy. 2014;59(9-10):3-9. (In Russ.)
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