ERCC1 как маркёр резистентности рака яичников к препаратам платины
Аннотация
Обзор посвящён важнейшему маркёру эксцизионной репарации нуклеотидов ERCC1 и его вкладу в резистентность рака яичников к препаратам платины. Рассмотрены все варианты лабораторного и клинического определения ERCC1 в ткани рака яичников (однонуклеотидные полиморфизмы гена ERCC1, уровень мРНК и белка). Систематизированы сведения о прогностической и предиктивной значимости ERCC1 в качестве маркёра эффективности платиносодержащей терапии рака яичников. Авторы обсуждают возможные причины разнородности результатов и подчёркивают необходимость унифицированного и интегрального подхода к исследованию ERCC1 в опухоли. Проанализированы работы, цитированные в поисковой системе Pub Med до января 2015 года.
Ключевые слова
Об авторах
Т. А. Богуш
Российский онкологический научный центр им. Н.Н. Блохина
Россия
Россия
А. С. Попова
Факультет фундаментальной медицины МГУ им. М.В. Ломоносова
Россия
Россия
Е. А. Дудко
Российский онкологический научный центр им. Н.Н. Блохина
Россия
Россия
Е. А. Богуш
Российский онкологический научный центр им. Н.Н. Блохина
Россия
Россия
А. С. Тюляндина
Российский онкологический научный центр им. Н.Н. Блохина
Россия
Россия
С. А. Тюляндин
Российский онкологический научный центр им. Н.Н. Блохина
Россия
Россия
М. И. Давыдов
Российский онкологический научный центр им. Н.Н. Блохина
Россия
Россия
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Рецензия
Для цитирования:
Богуш Т.А., Попова А.С., Дудко Е.А., Богуш Е.А., Тюляндина А.С., Тюляндин С.А., Давыдов М.И. ERCC1 как маркёр резистентности рака яичников к препаратам платины. Антибиотики и Химиотерапия. 2015;60(3-4):42-50.
For citation:
Bogush T.A., Popova A.S., Dudko E.A., Bogush E.A., Tyulyandina A.S., Tyulyandin S.A., Davydov M.I. ERCC1 as a Marker of Ovarian Cancer Resistance to Platinum Drugs. Antibiot Khimioter = Antibiotics and Chemotherapy. 2015;60(3-4):42-50. (In Russ.)
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