ANTIBACTERIAL PROPERTIES OF AMICOUMYCIN A
Abstract
The in vitro activity of the antibiotic amikumacin A against 22 collective test strains and 24 clinical isolates of bacteria and fungi was studied. It is shown that amicoumycin A has a broad antimicrobial spectrum of activity. The minimum inhibitory concentration (MIC) of amicoumycin A against methicillin-resistant Staphylococcus aureus (MRSA) and resistant to glycopeptide antibiotics of vancomycin group (VR) test strain Leuconostoc mesenteroides of 0.06 ^g/disk were established. In the study of multidrug-resistant clinical isolates, amikumacin A exhibited activity against S.aureus, S.epidermidis, C.krusei, Cr.neoformis and Prototheca spp. strains.
About the Authors
O. V. Efremenkova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
N. I. Gabrielyan
Academician V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
I. A. Malanicheva
Gause Institute of Antibiotics
Russian Federation
Russian Federation
T. A. Efimenko
Gause Institute of Antibiotics
Russian Federation
Russian Federation
I. G. Sumarukova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
A. A. Gluhova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
YU. V. Boykova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
E. A. Rogozhin
Gause Institute of Antibiotics
Russian Federation
Russian Federation
A. M. Korolev
Gause Institute of Antibiotics
Russian Federation
Russian Federation
V. A. Korshun
Gause Institute of Antibiotics
Russian Federation
Russian Federation
I. V. Drabkina
Academician V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
References
1. World Health Organization. Antimicrobial resistance. 2016. http://www.who.int/mediacentre/factsheets/fs194/en/
2. Butler M.S., Blaskovich M.A., Cooper M.A. Antibiotics in the clinical pipeline in 2013. J Antibiot2013; 66: 10: 571-591.
3. Ефименко Т.А., Маланичева И.А., Зенкова В.А., Королев А.М., Остерман И.А., Сергиев П.В., Ефременкова О.В. Изыскание антибиотиков, эффективных в отношении бактерий с лекарственной устойчивостью, на примере Bacillus pumilus - продуцента антибиотика амикумацина А. Вестник Оренбургского университета 2014; 13: 27-31, 150-151.
4. Маланичева И.А., Ефименко Т.А., Зенкова В.А., Королев А.М., Остерман И.А., Сергиев П.В., Ефременков О.В. Бактерии рода Bacillus - продуценты антибиотиков, преодолевающих лекарственную устойчивость болезнетворных микроорганизмов. Известия УНЦ РАН 2015; 4 (1): 98-101.
5. Itoh J., Omoto S., Shomura T., Nishizawa N., Miyado S., Yuda Y., Shibata U. Amicoumacin-A, a new antibiotic with antiinflammatory and antiulcer activity. J Antibiot1981; 34: 611-613.
6. Tyurin A.P., Efimenko T.A., Prokhorenko I.A., Rogozhin E.A., Malanicheva I.A., Zenkova V.A., Efremenkova O.V., Korshun V.A. Amicoumacins and related compounds: chemistry and biology. 2016; принята к печати.
7. Lama A., Pane-Farre J., Chon T., Wiersma A. M., Sit C. S., Vederas J. C., Hecker M., Nakano M. M. Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. PLoS One 2013; 7: e34037.
8. Polikanov Y.S., Osterman I.A., Szal T., Tashlitsky V.N., Serebryakova M.V., Kusochek P., Bulkley D., Malanicheva I.A., Efimenko T.A., Efremenkova O.V., Konevega A.L., Shaw K.J., Bogdanov A.A., Rodnina M.V., Dontsova O.A., Mankin A.S., Steitz T.A., Sergiev P.V. Amicoumacin A inhibits translation by stabilizing mRNA interaction with the ribosome. Mol Cell 2014; 56: 531-540.
Review
For citations:
Efremenkova O.V., Gabrielyan N.I., Malanicheva I.A., Efimenko T.A., Sumarukova I.G., Gluhova A.A., Boykova Yu.V., Rogozhin E.A., Korolev A.M., Korshun V.A., Drabkina I.V. ANTIBACTERIAL PROPERTIES OF AMICOUMYCIN A. Antibiot Khimioter = Antibiotics and Chemotherapy. 2017;62(1-2):16-19. (In Russ.)
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