ANTIBACTERIAL PROPERTIES OF AMICOUMYCIN A
Abstract
The in vitro activity of the antibiotic amikumacin A against 22 collective test strains and 24 clinical isolates of bacteria and fungi was studied. It is shown that amicoumycin A has a broad antimicrobial spectrum of activity. The minimum inhibitory concentration (MIC) of amicoumycin A against methicillin-resistant Staphylococcus aureus (MRSA) and resistant to glycopeptide antibiotics of vancomycin group (VR) test strain Leuconostoc mesenteroides of 0.06 ^g/disk were established. In the study of multidrug-resistant clinical isolates, amikumacin A exhibited activity against S.aureus, S.epidermidis, C.krusei, Cr.neoformis and Prototheca spp. strains.
About the Authors
O. V. Efremenkova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
N. I. Gabrielyan
Academician V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
I. A. Malanicheva
Gause Institute of Antibiotics
Russian Federation
Russian Federation
T. A. Efimenko
Gause Institute of Antibiotics
Russian Federation
Russian Federation
I. G. Sumarukova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
A. A. Gluhova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
YU. V. Boykova
Gause Institute of Antibiotics
Russian Federation
Russian Federation
E. A. Rogozhin
Gause Institute of Antibiotics
Russian Federation
Russian Federation
A. M. Korolev
Gause Institute of Antibiotics
Russian Federation
Russian Federation
V. A. Korshun
Gause Institute of Antibiotics
Russian Federation
Russian Federation
I. V. Drabkina
Academician V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
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Review
For citations:
Efremenkova OV, Gabrielyan NI, Malanicheva IA, Efimenko TA, Sumarukova IG, Gluhova AA, Boykova YV, Rogozhin EA, Korolev AM, Korshun VA, Drabkina IV. ANTIBACTERIAL PROPERTIES OF AMICOUMYCIN A. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2017;62(1-2):16-19. (In Russ.)
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