Биологические функции сукцината (обзор зарубежных экспериментальных исследований)

Проведён анализ зарубежных научных публикаций, отражающих современные представления о биологической роли сукцината - интермедиата цикла трикарбоновых кислот. Интерес зарубежных исследователей к сукцинату связан с изучением работы митохондрий при различных патофизиологических состояниях, открытием гипоксия-индуцибельного фактора HIF-1, а также с исследованиями генома человека, благодаря которым были обнаружены G-протеин-зависимые рецепторы, избирательно связывающиеся с сукцинатом. Согласно результатам зарубежных экспериментальных работ, помимо участия в реакциях биологического окисления, сукцинат играет важную роль в регуляции физиологических, метаболических и генетических процессов.

сукцинат, митохондриальная дисфункция, гипоксия-индуцибельный фактор, сукцинатные рецепторы, Реамберин, Цитофлавин

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