Change of Tumor Cell Multiple Drug Resistance Inhibitory Activity of Oligomycins in Complexes with Lithium and Zinc
Abstract
Oligomycins and their complexes with lithium and zinc were shown to be less active vs. cyclosporin A in inhibition of transport proteins responsible for multiple drug resistance of lymphoid leukosis P388VR cells, while certain oligomycin complexes were tens or hundreds times more active than cyclosporin A by inhibition of transport proteins in another type of tumor cells, i.e. human larynx cancer Hep-2, that makes possible the use of the oligomycins complexes with lithium and zinc for inhibition of multiple drug resistance of certain tumor types.
Keywords
About the Authors
M. V. Bibikova
Viorin
Russian Federation
Russian Federation
A. N. Danilenko
Emmanuel Institute of Biochemical Physics, Russian Academy of Science
Russian Federation
Russian Federation
A. V. Katlinsky
Fort
Russian Federation
Russian Federation
A. F. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Russian Federation
Russian Federation
L. N. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Russian Federation
Russian Federation
M. Kh. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Russian Federation
Russian Federation
V. V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Russian Federation
Russian Federation
Yu. N. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Russian Federation
Russian Federation
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Review
For citations:
Bibikova M.V., Danilenko A.N., Katlinsky A.V., Korystova A.F., Kublik L.N., Levitman M.Kh., Shaposhnikova V.V., Korystov Yu.N. Change of Tumor Cell Multiple Drug Resistance Inhibitory Activity of Oligomycins in Complexes with Lithium and Zinc. Antibiot Khimioter = Antibiotics and Chemotherapy. 2015;60(11-12):9-14. (In Russ.)
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