Preview

Antibiot Khimioter = Antibiotics and Chemotherapy

Advanced search

Clinical and Microbiological Aspects of Chronic Endometritis in Women of Reproductive Age

Abstract

Objective. Estimation of microbiocenosis of lower and upper genital tract in different morphological forms of chronic endometritis and endometrial polyps. Material and methods. Histological examination of endometrial aspirates and microview of the lower and upper genital tract in 164 women of reproductive age with different character of menstrual and reproductive history. Results. The risk of endometrial colonization in disturbance microecology of the vagina is 3.5 times higher than that in patients with normosenosis (р<0.01, ОР=3.5 [95% CI 1.63-8.11]). Conclusion. The microbiological diagnosis can be considered as a component of comprehensive diagnostics necessary to choose the appropriate management of patients with CE and PE.

About the Authors

L. A. Marchenko
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


G. E. Chernukha
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


O. V. Yakushevskaya
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


N. A. Gombolevskaya
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


V. V. Muravieva
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


T. V. Priputnevich
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


A. S. Ankirskaya
Research Center for Obstetrics, Gynecology and Perinatology named after Academician Vladimir Kulakov
Russian Federation


References

1. Шуршалина A.B. Роль хронического эндометрита в развитии патологии репродуктивной функции. Росс мед журн 2007; 4: 25-27

2. Cicinelli E., Matteo M., Tinelli R., Lepera A., Alfonso R., Indraccolo U., Marrocchella S., Greco P., Resta L. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod 2014 Nov 10. pii: deu292.

3. Johnston-MacAnanny E.B., Hartnett J., Engmann L.L., Nulsen J.C., Sanders M.M., Benadiva C.A. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil Steril 2010; 93: 2: 437-441.

4. McQueen D.B., Bernardi L.A., Stephenson M.D. Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertil Steril. 2014 Apr; 101: 4: 1026-1030.

5. Carvalho F.M., Aguiar F.N., Tomioka R., Oliveira R.M., Frantz N., Ueno J. Functional endometrial polyps in infertile asymptomatic patients: a possible evolution of vascular changes secondary to endometritis. Eur J Obst Gynecol Reprod Biol 2013; 170: 152-156.

6. Ju J., Li L., Xie J., Wu Y., Wu X., Li W. Toll-like receptor-4 pathway is required for the pathogenesis of human chronic endometritis. Exp Ther Med 2014 Dec; 8: 6: 1896-1900.

7. Matteo M., Cicinelli E., Greco P., Massenzio F., Baldini D., Falagario T. et al. Abnormal pattern of lymphocyte subpopulations in the endometrium of infertile women with chronic endometritis. Am J Reprod Immunol 2009; 61: 5: 322-329.

8. Анкирская A.C., Муравьева B.B. Интегральная оценка состояния микробиоты влагалища. Диагностика оппортунистических вагинитов (медицинская технология). М.: 2011; 10-13

9. Andrews W.W., Hauth J.C., Cliver S.P., Conner M.G., Goldenberg R.L., Goepfert A.R. Association of asymptomatic bacterial vaginosis with endometrial microbial colonization and plasma cell endometritis in nonpregnant women. Am J Obstet Gynecol 2006; 195: 6: 1611-1616.

10. Polisseni F., Bambirra E.A., Camargos A.F. Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients. Gynecol Obstet Invest 2003; 55: 4: 205-210.

11. Rivlin M.E. Endometritis treatment and management. Jan. 2015. Overview. www.Medscape.com

12. Клинышкова T.B., Фролова Н.Б., Мозговой С.И. Клиническое значение комплексной оценки рецепторного статуса эндометрия при эндометриальных полипах. Журн акушер гинекол 2003; 3.

13. Шешукова H.A., Макаров И.О., Овсянникова T.B. Гиперпластические процессы эндометрия: особенности пролиферативной активности при сочетании с хроническим эндометритом. Акушер гинекол репрод 2011; 3: 10-15

14. Haggerty C.L, Hillier S.L., Bass D.C., Ness R.B.; PID Evaluation and Clinical Health study investigators. Bacterial vaginosis and anaerobic bacteria are associated with endometritis. Clin Infect Dis 2004; 39: 7: 990-995.

15. Pelzer E.S., Dana L.W., Buttini M., Huygens F. A role for the endometrial microbiome in dysfunctional menstrual bleeding. http://esa-srb-2013.m.asnevents. com.au/schedule /abstract/7389.

16. Rivlin M.E, Former M.D. Endometritis Treatment & Management. 2015. www.medscape.com.

17. Andrews W.W., Goldenberg R.L., Hauth J.C., Cliver S.P., Copper R., Conner M. Interconceptional antibiotics to prevent spontaneous preterm birth: a randomized clinical trial. Am J Obstet Gynecol 2006; 194: 3: 617-623.

18. Swidsinski A1, Verstraelen H., Loening-Baucke V., Swidsinski S., Mendling W., Halwani Z. Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One. 2013; 8: 1: e53997.


Review

For citations:


Marchenko L.A., Chernukha G.E., Yakushevskaya O.V., Gombolevskaya N.A., Muravieva V.V., Priputnevich T.V., Ankirskaya A.S. Clinical and Microbiological Aspects of Chronic Endometritis in Women of Reproductive Age. Antibiot Khimioter = Antibiotics and Chemotherapy. 2016;61(9-10):44-51. (In Russ.)

Views: 327


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0235-2990 (Print)